RADIORYTHMIC : Phase III, Opened, Randomized Study of Postoperative Radiotherapy Versus Surveillance in Stage IIb/III of Masaoka Koga Thymoma after Complete Surgical Resection

C. Basse , A. Botticella , T.J. Molina , P.E. Falcoz , Y. Oulkhouir , M. Kerjouan , E. Pichon , V. Westeel , L. Thiberville (1) , X. Quantin , C. Clément-Duchêne , J. Khalifa , F.L. Tinier , M. Ginoux , F. Thillays , P. Mordant , B. Besse , P.A. Thomas , C.L. Péchoux , N. Girard

1 QuantIF-LITIS - Equipe Quantification en Imagerie Fonctionnelle

Thymomas are rare intrathoracic malignancies that may be aggressive and difficult to treat. Knowledge and level of evidence for treatment strategies are mainly based on retrospective studies or expert opinion. Currently there is no strong evidence that postoperative radiotherapy after complete resection of localized thymoma is associated with survival benefit in patients. RADIORYTHMIC is a phase III, randomized trial aiming at comparing postoperative radiotherapy versus surveillance after complete resection of Masaoka-Koga stage IIb/III thymoma. Systematic central pathologic review will be performed before patient enrollment as per the RYTHMIC network pathway.

Mots clés: Network; Postoperative radiotherapy; Surgery; Surveillance; Thymoma

Domaines: Sciences du Vivant [q-bio]

C. Basse, A. Botticella, T.J. Molina, P.E. Falcoz, Y. Oulkhouir, et al.. RADIORYTHMIC : Phase III, Opened, Randomized Study of Postoperative Radiotherapy Versus Surveillance in Stage IIb/III of Masaoka Koga Thymoma after Complete Surgical Resection. Clinical Lung Cancer, 2021, ⟨10.1016/j.cllc.2021.01.020⟩. ⟨hal-03226297⟩