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Diterpenoids from the Mediterranean Brown Alga Dictyota sp. Evaluated as Antifouling Substances against a Marine Bacterial Biofilm

Abstract : Four new cyclized diterpenes, one xenicane (1) and three dolabellanes (2-4), were isolated, along with seven previously reported metabolites [3beta-hydroxydilophol (5), dictyols E (6) and C (7), hydroxycrenulide (8), 9-acetoxy-15-hydroxy-1,6-dollabelladiene (9), hydroxyacetyldictyolal (10), and fucoxanthin], from a Mediterranean species of Dictyota sp. collected in Le Brusc Lagoon (French Mediterranean coast). Their structures, as well as their relative configurations, were determined through extensive spectrometric (IR, HRESIMS, 1D and 2D NMR) data analysis and molecular modeling studies and by comparison with those reported in literature. Some of the isolated metabolites were evaluated for their antiadhesion activity against a marine bacterial biofilm (Pseudoalteromonas sp. D41).
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https://hal.archives-ouvertes.fr/hal-03184235
Contributor : Mercedes Jardin Camps <>
Submitted on : Monday, March 29, 2021 - 12:14:59 PM
Last modification on : Tuesday, March 30, 2021 - 11:18:02 AM

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Yannick Viano, Dominique Bonhomme, Mercedes Camps, Jean-François Briand, Annick Ortalo-Magné, et al.. Diterpenoids from the Mediterranean Brown Alga Dictyota sp. Evaluated as Antifouling Substances against a Marine Bacterial Biofilm. Journal of Natural Products, American Chemical Society, 2009, 72 (7), pp.1299-1304. ⟨10.1021/np900102f⟩. ⟨hal-03184235⟩

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