Promiscuity of Carbonic Anhydrase II. Unexpected Ester Hydrolysis of Carbohydrate-Based Sulfamate Inhibitors

Marie Lopez (1) , Hoan Vu (1) , Conan Wang (1) , Maarten Wolf (2) , Gerrit Groenhof (2) , Alessio Innocenti (3) , Claudiu Supuran (3) , Sally-Ann Poulsen (1)

1 Eskitis Institute for Drug Discovery
2 Biomolecular Chemistry Group, Theoretical and Computational Biophysics Department, Max Planck Institute of Biophysical Chemistry
3 LCBI-UniFI - Laboratorio di Chimica Bioinorganica [UniFI, Firenze] = Laboratory of Bioinorganic Chemistry [UniFI Florence]

Domaines: Chimie organique; Chimie thérapeutique; Cristallographie; Cancer

Marie Lopez, Hoan Vu, Conan Wang, Maarten Wolf, Gerrit Groenhof, et al.. Promiscuity of Carbonic Anhydrase II. Unexpected Ester Hydrolysis of Carbohydrate-Based Sulfamate Inhibitors. Journal of the American Chemical Society, 2011, 133 (45), pp.18452-18462. ⟨10.1021/ja207855c⟩. ⟨hal-03129971⟩