Evidence for continuing cross-species transmission of SIVsmm to humans : characterization of a new HIV-2 lineage in rural Côte d’Ivoire

Ahidjo Ayouba (1) , C Akoua-Koffi (2) , S Calvignac-Spencer (3) , A Esteban (1) , Sabrina Locatelli (1) , H Li (4) , Y Li (4) , Bh Hahn (4) , E Delaporte (1) , Fh Leendertz (3) , M. Peeters (1)

1 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
2 University of Alassane Ouattara [Bouaké, Côte d’Ivoire]
3 RKI - Robert Koch Institute [Berlin]
4 HUP - Hospital of the University of Pennsylvania

HIV types 1 and 2 (HIV-1 and HIV-2) are the result of multiple cross-species transmissions of their simian counterparts (SIVs) to humans. We studied whether new SIVs lineages have been transmitted to humans in rural Côte d’Ivoire and identified a novel HIV-2 variant (HIV-2-07IC- TNP03) not related to any of the previously defined HIV-2 groups. This finding shows that sooty mangabey viruses continue to be transmitted to humans, causing new zoonotic outbreaks.

Domaines: Santé publique et épidémiologie

Ahidjo Ayouba, C Akoua-Koffi, S Calvignac-Spencer, A Esteban, Sabrina Locatelli, et al.. Evidence for continuing cross-species transmission of SIVsmm to humans : characterization of a new HIV-2 lineage in rural Côte d’Ivoire. AIDS. Official journal of the international AIDS Society, 2013, 27 (15), pp.2488-2491. ⟨10.1097/01.aids.0000432443.22684.50⟩. ⟨hal-03054435⟩