The events that may contribute to subgingival dysbiosis a focus on the interplay between iron, sulfide and oxygen

Kanchana Chathoth (1) , Bénédicte Martin (1) , Pierre Cornelis (2, 3) , Stéven Yvenou (1) , Martine Bonnaure-Mallet (1, 4) , Christine Baysse (1)

1 NuMeCan - Nutrition, Métabolismes et Cancer
2 VUB - Vrije Universiteit Brussel
3 LMSM - Laboratoire de Microbiologie Signaux et Microenvironnement
4 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]

This minireview considers the disruption of the host-microbiota harmless symbiosis in the subgingival niche. The establishment of a chronic infection by subversion of a commensal microbiota results from a complex and multiparametric sequence of events. This review narrows down to the interplay between oxygen, iron and sulfide that can result in a vicious cycle that would favor peroxygenic and glutathione producing streptococci as well as sulfidogenic anaerobic pathogens in the subgingival niche. We propose hypothesis and discuss strategies for the therapeutic modulation of the microbiota to prevent periodontitis and promote oral health.

Mots clés: hydrogen peroxide; hydrogen sulfide; iron; oral biofilm; oxygen

Domaines: Sciences du Vivant [q-bio]; Microbiologie et Parasitologie

Kanchana Chathoth, Bénédicte Martin, Pierre Cornelis, Stéven Yvenou, Martine Bonnaure-Mallet, et al.. The events that may contribute to subgingival dysbiosis a focus on the interplay between iron, sulfide and oxygen. FEMS Microbiology Letters, 2020, 367 (14), pp.fnaa100. ⟨10.1093/femsle/fnaa100⟩. ⟨hal-02930388⟩