Expanded comparative mapping between man and rabbit and detection of a new conserved segment between HSA22 and OCU4

Céline Chantry-Darmon (1) , Maud Bertaud (2) , Celine C. Urien (1) , Sead S. Chadi (2) , M. Perrocheau (2) , Claire Rogel Gaillard (3) , Hélène Hayes (2)

1 VIM (UR 0892) - Unité de recherche Virologie et Immunologie Moléculaires
2 LGBC - Unité de recherche Génétique Biochimique et Cytogénétique
3 LREG - Laboratoire de radiobiologie et d'étude du génome

Rabbit, a domestic species exploited both in animal production and medical research has only recently begun to be included in gene mapping projects, in particular by the French National Institute of Agronomics. By 2002, less than 60 genes had been precisely localised on rabbit chromosomes, which led us to start a large-scale project on gene mapping in rabbit with the publication of 133 gene localisations in 2003 (Chantry-Darmon et al., 2003). Here, we report the localisation of 102 new genes resulting in good coverage of the rabbit genome and an eight-fold enrichment of the gene map. In addition, we have detected a new conserved segment between rabbit chromosome 4q15.3 and part of human chromosome 22 and thus improved the comparative map with the human genome.

Domaines: Génétique

Céline Chantry-Darmon, Maud Bertaud, Celine C. Urien, Sead S. Chadi, M. Perrocheau, et al.. Expanded comparative mapping between man and rabbit and detection of a new conserved segment between HSA22 and OCU4. Cytogenetic and Genome Research, 2005, 111, pp.134-139. ⟨hal-02672083⟩