Meiotic studies of a 38,XY/39,XXY mosaic boar

Alain Pinton (1) , Harmonie Barasc (1) , I. Raymond Letron (2) , Matthieu Bordedebat (1) , Nicolas Mary (1) , K. Massip (1) , N. Bonnet (1) , Anne Calgaro (1) , Anne-Marie Dudez (1) , Katia K. Feve (1) , Juliette Riquet (1) , Martine M. Yerle (1) , Alain Ducos (1)

1 LGC - Laboratoire de Génétique Cellulaire
2 ENVT - Ecole Nationale Vétérinaire de Toulouse

Klinefelter’s syndrome (KS) is the most common sex chromosome abnormality identified in human males. This syndrome is generally associated with infertility. Men with KS may have a 47,XXY or a 46,XY/47,XXY karyotype. Studies carried out in humans and mice suggest that only XY cells are able to enter and complete meiosis. These cells could originate from the XY cells present in mosaic patients or from XXY cells that have lost one X chromosome. In pig, only 3 cases of pure 39,XXY have been reported until now, and no meiotic analysis was carried out. For the first time in pig species we report the analysis of a 38,XY/39,XXY boar and describe the origin of the supplementary X chromosome and the chromosomal constitutions of the germ and Sertoli cells.

Mots clés: klinefelter; pig

Mots clés: meiosis; mosaic

Domaines: Sciences du Vivant [q-bio]

Alain Pinton, Harmonie Barasc, I. Raymond Letron, Matthieu Bordedebat, Nicolas Mary, et al.. Meiotic studies of a 38,XY/39,XXY mosaic boar. Cytogenetic and Genome Research, 2011, 133 (2-4), pp.202-208. ⟨10.1159/000321794⟩. ⟨hal-02646915⟩