The nutritional status affects the complete blood count of goats experimentally infected with Haemonchus contortus

Steve Ceriac (1) , Cyntia Jayles (2) , Rémy Arquet (2) , Dalila Feuillet (1) , Yoann Felicite (1) , Harry Archimède (1) , Jean-Christophe Bambou (1)

1 URZ - Unité de Recherches Zootechniques
2 PTEA - Plateforme Tropicale d'Expérimentation sur l'Animal

Background: Gastrointestinal nematode (GIN) remains the most important pathogenic constraint of small ruminant production worldwide. The improvement of the host immune response against GIN though breeding for improved animal resistance, vaccination and nutritional supplementation appear as very promising methods. The objective of this study was to investigate the effect of four nutritional status differing in protein and energy levels (Hay: 5.1 MJ/Kg of dry matter (DM) and 7.6% of crude protein (CP), Ban: 8.3 MJ/Kg of DM and 7.5% of CP, Soy: 7.6 MJ/Kg of DM and 17.3% of CP, BS: 12.7 MJ/Kg of DM and 7.4% of CP) on the haematological disturbances due to Haemonchus contortus infection in Creole kid goats. Results: No significant effect of the nutritional status was observed for faecal egg count (FEC) but the experimental infection induced haematological disturbances whose intensity and lengthening were dependent on the nutritional status. A transient marked regenerative macrocytic hypochromic anaemia as revealed by a decrease of packed cell volume (PCV), red blood cells (RBC) and hemoglobin and an increase of reticulocytes was observed in all infected groups except Hay. In this latter, the anaemia settled until the end of the experiment. Furthermore, H. contortus induced a thrombocytopenia significantly more pronounced in the group under the lowest nutritional status in term of protein (Hay and Ban). A principal component analysis revealed that the variables that discriminated the nutritional status were the average daily gain (ADG) and the PCV, considered as measures of the level of resilience to H. contortus infection. Moreover, the variables that discriminated infected and non-infected animals were mostly related to the biology of RBC (i.e. size and hemoglobin content) and they were correlated with FEC. Conclusions: The severity and the lengthening of the regenerative anaemia and the thrombocytopenia induced by H. contortus have been affected by the nutritional status. The protein enriched diets induced resilience to the infection rather than resistance. This suggests that resilience is associated with an improved regenerative capacity of the bone marrow. However, this needs to be further investigated to understand the relationships between resistance, resilience and dietary supplementation.

Mots clés: blood cells; goats

Mots clés: gastrointestinal nematode; nutrition

Domaines: Sciences du Vivant [q-bio]; Génétique; Génétique animale

Steve Ceriac, Cyntia Jayles, Rémy Arquet, Dalila Feuillet, Yoann Felicite, et al.. The nutritional status affects the complete blood count of goats experimentally infected with Haemonchus contortus. BMC Veterinary Research, 2017, 13 (1), ⟨10.1186/s12917-017-1248-4⟩. ⟨hal-02624439⟩