Assessment of agreement and time in therapeutic range of capillary versus venous international normalised ratio in frail elderly people in a nursing home

Chloé Sikirdji (1) , David Costa (2, 3) , Sandrine Alonso (3, 4) , Jean-François Clape (1, 2) , Michel Amouyal (2) , Benoît de Waziere (1, 2) , Pascale Fabbro-Peray (4)

1 EHPAD de l'Hôpital de Pont Saint Esprit
2 UM - Université de Montpellier
3 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
4 BESPIM

Vitamin K antagonists are widely used, yet have a slim therapeutic margin and high iatrogenicity. Patients are monitored through international normalised ratio (INR) by venipuncture, but coagulometers could measure INR by capillary puncture. This prospective study evaluated the clinical concordance of capillary INR versus venous INR in 31 nursing home patients. Concordance was good and mean time in therapeutic range (TTR) markedly increased. Capillary INR is thus reliable, could improve TTR and decrease iatrogenicity.

Mots clés: coagulometer; elderly; international normalised ratio; point-of-care testing; vitamin K antagonist

Domaines: Biophysique

Chloé Sikirdji, David Costa, Sandrine Alonso, Jean-François Clape, Michel Amouyal, et al.. Assessment of agreement and time in therapeutic range of capillary versus venous international normalised ratio in frail elderly people in a nursing home. Internal Medicine Journal, 2019, 49 (11), pp.1442-1446. ⟨10.1111/imj.14626⟩. ⟨hal-02563476⟩