Restoration of chloride efflux by azithromycin in airway epithelial cells of cystic fibrosis patients

Vinciane Saint-Criq (1, 2) , Carine Rebeyrol (1, 2) , Manon Ruffin (1, 2) , Telma Roque (1, 2) , Loïc Guillot (1, 2) , Jacky Jacquot (1, 2) , Annick Clement (1, 2, 3) , Olivier Tabary (1, 2)

1 CRSA - Centre de Recherche Saint-Antoine
2 UPMC - Université Pierre et Marie Curie - Paris 6
3 CHU Trousseau [APHP]

Azithromycin (AZM) has shown promising anti-inflammatory properties in chronic obstructive pulmonary diseases, and clinical studies have presented an improvement in the respiratory condition of cystic fibrosis (CF) patients. The aim of this study was to investigate, in human airway cells, the mechanism by which AZM has beneficial effects in CF. We demonstrated that AZM did not have any anti-inflammatory effect on CF airway cells but restored Cl- efflux.

Domaines: Sciences du Vivant [q-bio]

Vinciane Saint-Criq, Carine Rebeyrol, Manon Ruffin, Telma Roque, Loïc Guillot, et al.. Restoration of chloride efflux by azithromycin in airway epithelial cells of cystic fibrosis patients. Antimicrobial Agents and Chemotherapy, 2011, 55 (4), pp.1792-1793. ⟨10.1128/AAC.01403-10⟩. ⟨hal-02405807⟩