Insomnia, Daytime Sleepiness and Cardio- Cerebrovascular Diseases in the Elderly: A 6-Year Prospective Study

Isabelle Jaussent (1, 2) , Jean-Philippe Empana (3) , Marie-Laure Ancelin (1, 2) , Alain Besset (1, 2) , Catherine Helmer (4) , Christophe Tzourio (4) , Karen A. Ritchie (5, 1) , Jean Bouyer (6) , Yves Dauvilliers (7, 1)

1 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
2 UM - Université de Montpellier
3 PARCC - UMR-S U970 - Paris-Centre de Recherche Cardiovasculaire
4 Epidémiologie et Biostatistique [Bordeaux]
5 Imperial College London
6 CESP - Centre de recherche en épidémiologie et santé des populations
7 CHU Montpellier

Objective: To examine 1) the associations between history of cardio-cerebrovascular diseases (CVD) and insomnia complaints and excessive daytime sleepiness (EDS), and 2) the relationships between sleep complaints and future CVD in persons over 65. Methods: CVD was assessed at baseline and during two, four, and six-year follow-up in 5494 non-demented subjects. Self-reported insomnia complaints (poor sleep quality, difficulty in initiating sleep, difficulty in maintening sleep, and early morning awakening), EDS and sleep medication use were evaluated at baseline. Logistic regression models and Cox proportional hazard models, with delayed entry and age of participants as the time scale, were adjusted for socio-demographic, lifestyle and clinical variables. Results: At baseline, 748 participants had a past-history of CVD. A past-history of CVD was associated with EDS (OR = 1.28 95%CI = [1.05-1.57]) and the number of insomnia complaints (OR = 1.26 95%CI = [1.03-1.55] for 1-2 insomnia complaints; OR = 1.32 95%CI = [1.03-1.71] for $3 complaints). In longitudinal analyses, neither the four components of insomnia nor the number of insomnia complaints were significantly associated with first or recurrent CVD events (n = 391 events). EDS was independently associated with future CVD events even after adjusting for prescribed sleep medication and past-history of CVD (HR = 1.35 95%CI = [1.06-1.71]). Conclusion: Our results suggest that the relationships between sleep complaints and CVD could be complex. Insomnia complaints are more likely a consequence of CVD, whereas EDS appears to be a determinant of CVD independently of past-history of CVD. EDS screening may thus constitute a means of detecting persons at high risk of CVD. Citation: Jaussent I, Empana J-P, Ancelin M-L, Besset A, Helmer C, et al. (2013) Insomnia, Daytime Sleepiness and Cardio-Cerebrovascular Diseases in the Elderly: A 6-Year Prospective Study. PLoS ONE 8(2): e56048.

Mots clés: Sleep; Insomnia; Cardiovascular diseases; Hypertension; Elderly; Geriatrics; Diabetes mellitus; Geriatric depression

Domaines: Médecine humaine et pathologie

Isabelle Jaussent, Jean-Philippe Empana, Marie-Laure Ancelin, Alain Besset, Catherine Helmer, et al.. Insomnia, Daytime Sleepiness and Cardio- Cerebrovascular Diseases in the Elderly: A 6-Year Prospective Study. PLoS ONE, 2013, 8 (2), pp.e56048. ⟨10.1371/journal.pone.0056048⟩. ⟨hal-02398368⟩