Autoimmune manifestations associated with lymphoma: characteristics and outcome in a multicenter retrospective cohort study

Vincent Jachiet (1, 2) , Arsène Mekinian (1) , Fabrice Carrat (3, 1) , Eric Grignano (4, 5) , Aurelia Retbi (1) , Jean-Jacques Boffa (6) , Pierre Ronco (7, 8) , Eric Rondeau (7) , Jérémie Sellam (9) , Francis Berenbaum (9) , Olivier Chazouillères (1) , Jean Capron (1) , Sonia Alamowitch (10) , Francois Chasset (7, 11) , Camille Frances (7, 11) , Paul Coppo (12) , Olivier Fain (1, 2, 9)

1 CHU Saint-Antoine [AP-HP]
2 SU FM - Sorbonne Université - Faculté de Médecine
3 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
4 Hôpital Cochin [AP-HP]
5 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
6 UMR S702 - Remodelage et Reparation du Tissu Renal
7 CHU Tenon [AP-HP]
8 Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation
9 CRSA - Centre de Recherche Saint-Antoine
10 UPMC - Université Pierre et Marie Curie - Paris 6
11 SU - Sorbonne Université
12 PSL - Univ Paris 06

This French multicenter retrospective cohort study aimed to describe the autoimmune manifestations (AIMs) associated with lymphoma among patients hospitalized between 2005 and 2016 in three French University Hospitals. Among 2503 patients with lymphoma, 108 (4.3%) had AIMs, mostly autoimmune cytopenias (71.3%), neurological diseases (10.2%), kidney diseases (6.5%), systemic vasculitis (5.6%) and others. As compared with the 2395 lymphoma patients without AIMs, those with AIMs were older (p = .01), more frequently had B-cell chronic lymphocytic leukemia (p < .01) and less frequently diffuse large B-cell lymphomas (p = .01) and Hodgkin lymphoma (p = .01). The 5-year overall survival with lymphoma was 65% and 79% (p = .03) with and without AIMs. This large cohort study shows that various types of AIMs, mostly cytopenias, could be associated with lymphoma and affect the overall outcome with lymphoma, in particular for B-cell non-Hodgkin lymphoma (p = .01) and T-cell non-Hodgkin lymphoma (p = .01), with no survival difference noted for other types of lymphoma (p = .2).

Domaines: Urologie et Néphrologie

Vincent Jachiet, Arsène Mekinian, Fabrice Carrat, Eric Grignano, Aurelia Retbi, et al.. Autoimmune manifestations associated with lymphoma: characteristics and outcome in a multicenter retrospective cohort study. Leukemia & lymphoma, 2018, 59 (6), pp.1399-1405. ⟨10.1080/10428194.2017.1379075⟩. ⟨hal-03915988⟩