Classification of Metal-Based Drugs according to Their Mechanisms of Action

Eszter Boros , Paul Dyson (1) , Gilles Gasser (2)

1 Institut des Sciences et Ingénierie Chimiques
2 ENSCP - Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL

Metal-based drugs and imaging agents are extensively used in the clinic for the treatment and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of compounds operate via a limited number of mechanisms, whereas new putative compounds explore alternative mechanisms of action, which could potentially bring new chemotherapeutic approaches into the clinic. In this review, metal-based drugs and imaging agents are characterized according to their primary mode of action and the key properties and features of each class of compounds are defined, wherever possible. A better understanding of the roles played by metal compounds at a mechanistic level will help to deliver new metal-based therapies to the clinic, by providing an alternative, targeted and rational approach, to supplement non-targeted screening of novel chemical entities for biological activity.

Mots clés: Medicinal Inorganic Chemistry; Bioinorganic Chemistry; Metal-based drugs

Domaines: Chimie; Chimie thérapeutique

Eszter Boros, Paul Dyson, Gilles Gasser. Classification of Metal-Based Drugs according to Their Mechanisms of Action. Chem, 2019, ⟨10.1016/j.chempr.2019.10.013⟩. ⟨hal-02355351⟩