Polyphenols in human nutrition: from the in vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability - an overview and perspective

Abstract : Oxidative damage of cells and tissues is broadly implicated in human pathophysiology, including cardiometabolic diseases. Polyphenols, as important constituents of human diet and potent in vitro free radical scavengers, have been extensively studied for their beneficial effects on cardiometabolic health. However, it has been demonstrated that the in vivo antioxidant activity of polyphenols is distinct from their in vitro free radical scavenging capacity. Indeed, bioavailability of nutritional polyphenols is low, and conditioned by complex mechanisms of absorption, distribution, metabolism and excretion. Nowadays it is commonly accepted that the cellular antioxidant activity of polyphenols is mainly carried out via modification of transcription of genes involved in antioxidant defense. Importantly, polyphenols contribute to the cardiometabolic health also by modulation of plethora of cellular processes that are not directly associated with antioxidant enzymes, through nutri(epi)genomic mechanisms. Numerous human intervention studies have demonstrated beneficial effects of polyphenols on the key cardiometabolic risk factors. However, inconsistency of the results of some studies led to identification of the inter-individual variability in response to consumption of polyphenols. In perspective, a detailed investigation of the determinants of this inter-individual variability will potentially lead us towards personalized dietary recommendations. The phenomenon of inter-individual variability is also of relevance for supplementation with antioxidant (pro)vitamins.
Document type :
Journal articles
Complete list of metadatas

Cited literature [60 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02352500
Contributor : Archive Ouverte Prodinra <>
Submitted on : Wednesday, November 6, 2019 - 8:11:20 PM
Last modification on : Saturday, November 9, 2019 - 1:50:10 AM

File

2019_Ruskovska_Polyphenols_Br ...
Explicit agreement for this submission

Identifiers

Collections

Citation

T. Ruskovska, V. Maksimova, Dragan Milenkovic. Polyphenols in human nutrition: from the in vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability - an overview and perspective. British Journal of Nutrition, Cambridge University Press (CUP), 2019, pp.1-36. ⟨10.1017/s0007114519002733⟩. ⟨hal-02352500⟩

Share

Metrics

Record views

13

Files downloads

14