The emerging role of the transcriptional coregulator RIP140 in solid tumors

Marion Lapierre (1) , Aurélie Docquier (1) , Audrey Castet-Nicolas (1) , Delphine Gitenay (1) , Stéphan Jalaguier (1) , Catherine Teyssier (1) , Vincent Cavaillès (1)

1 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier

RIP140 is a transcriptional coregulator (also known as NRIP1) which plays very important physiological roles by finely tuning the activity of a large number of transcription factors. Noticeably, the RIP140 gene has been shown to be involved in the regulation of energy expenditure, in mammary gland development and intestinal homeostasis as well as in behavior and cognition. RIP140 is also involved in the regulation of various oncogenic signaling pathways and participates in the development and progression of solid tumors. This short review aims to summarize the role of this transcription factor on nuclear estrogen receptors, E2F and Wnt signaling pathways based on recent observations focusing on breast, ovary, liver and colon tumors.

Mots clés: Breast; Cancer; Colon; Liver; NRIP1/RIP140; Nuclear signaling; Ovary

Domaines: Médecine humaine et pathologie

Marion Lapierre, Aurélie Docquier, Audrey Castet-Nicolas, Delphine Gitenay, Stéphan Jalaguier, et al.. The emerging role of the transcriptional coregulator RIP140 in solid tumors. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2015, 1856 (1), pp.144-150. ⟨10.1016/j.bbcan.2015.06.006⟩. ⟨hal-02316634⟩