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Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus

Abstract : Several studies have demonstrated that electrical activation of the peripheral vestibular system can evoke field potential, multi-unit neuronal activity and acetylcholine release in the hippocampus (HPC). However, no study to date has employed the immediate early gene protein, c-Fos, to investigate the distribution of activation of cells in the HPC following electrical stimulation of the vestibular system. We found that vestibular stimulation increased the number of animals expressing c-Fos in the dorsal HPC compared to sham control rats (P ≤ 0.02), but not in the ventral HPC. c-Fos was also expressed in an increased number of animals in the dorsal dentate gyrus (DG) compared to sham control rats (P ≤ 0.0001), and to a lesser extent in the ventral DG (P ≤ 0.006). The results of this study show that activation of the vestibular system results in a differential increase in the expression of c-Fos across different regions of the HPC.
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Submitted on : Thursday, October 3, 2019 - 4:06:46 PM
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Martin Hitier, Go Sato, Yan-Feng Zhang, Stéphane Besnard, Paul Smith. Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus. Neuroscience Letters, Elsevier, 2018, 677, pp.60-64. ⟨10.1016/j.neulet.2018.04.041⟩. ⟨hal-02304973⟩

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