S. Alboni, R. M. Van-dijk, S. Poggini, G. Milior, M. Perrotta et al., Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment, Mol. Psychiatry, vol.22, pp.552-561, 2017.

K. S. Al-harbi, Treatment-resistant depression: therapeutic trends, challenges, and future directions, Patient Prefer. Adherence, vol.6, pp.369-388, 2012.

H. Amini-khoei, E. Haghani-samani, M. Beigi, A. Soltani, G. R. Mobini et al., On the role of corticosterone in behavioral disorders, microbiota composition alteration and neuroimmune response in adult male mice subjected to maternal separation stress, Int. Immunopharmacol, vol.66, pp.242-250, 2019.

J. D. Amsterdam, J. Fawcett, F. M. Quitkin, F. W. Reimherr, J. F. Rosenbaum et al., Fluoxetine and norfluoxetine plasma concentrations in major depression: a multicenter study, Am. J. Psychiatry, vol.154, pp.963-969, 1997.

C. Anacker and R. Hen, Adult hippocampal neurogenesis and cognitive flexibility -linking memory and mood, Nat. Rev. Neurosci, vol.18, pp.335-346, 2017.

J. H. Andresen, E. M. Løberg, M. Wright, I. L. Goverud, B. Stray-pedersen et al., Nicotine affects the expression of brainderived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets, J. Perinat. Med, vol.37, pp.553-560, 2009.

M. T. Bailey, S. E. Dowd, J. D. Galley, A. R. Hufnagle, R. G. Allen et al., Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation, Brain Behav. Immun, vol.25, pp.397-407, 2011.

P. L. Ballard, J. D. Baxter, S. J. Higgins, G. G. Rousseau, and G. M. Tomkins, General presence of glucocorticoid receptors in mammalian tissues, Endocrinology, vol.94, pp.998-1002, 1974.

M. Banasr, G. W. Valentine, X. Li, S. L. Gourley, J. R. Taylor et al., Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat, Biol. Psychiatry, vol.62, pp.496-504, 2007.

A. Bharwani, M. F. Mian, J. A. Foster, M. G. Surette, J. Bienenstock et al., Structural & functional consequences of chronic psychosocial stress on the microbiome & host, Psychoneuroendocrinology, vol.63, pp.217-227, 2016.

A. Blasco-serra, E. M. González-soler, A. Cervera-ferri, V. Teruel-martí, and A. A. Valverde-navarro, A standardization of the novelty-suppressed feeding test protocol in rats, Neurosci. Lett, vol.658, pp.73-78, 2017.

S. R. Bodnoff, B. Suranyi-cadotte, D. H. Aitken, R. Quirion, and M. J. Meaney, The effects of chronic antidepressant treatment in an animal model of anxiety, Psychopharmacology, vol.95, pp.298-302, 1988.

Y. Boumrah, T. Gicquel, C. Hugbart, A. Baert, I. Morel et al., Suicide by self-injection of chlormequat trademark C5SUN §, Forensic Sci. Int, vol.263, pp.9-13, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01295647

A. Caspi, Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene, Science, vol.301, pp.386-389, 2003.

C. Clouard, M. Jouhanneau, M. Meunier-salaün, C. Malbert, and D. Vallaillet, Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs, PLoS One, vol.7, p.37968, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01210334

C. Clouard, M. C. Meunier-salaün, and D. Laillet, Food preferences and aversions in human health and nutrition: how can pigs help the biomedical research? Anim, Int. J. Anim. Biosci, vol.6, pp.118-136, 2012.

N. Coquery, Intrahippocampal Transplantation of MSC and MSCExpressing BDNF in Rat Models of Depression-like Behaviour, 2009.

N. Coquery, P. Meurice, R. Janvier, E. Bobillier, S. Quellec et al., fMRI-based brain responses to quinine and sucrose gustatory stimulation for nutrition research in the minipig model: a proof of concept study, Front. Behav. Neurosci, vol.12, p.151, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01856969

C. Crochemore, J. Lu, Y. Wu, Z. Liposits, N. Sousa et al., Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation, Mol. Psychiatry, vol.10, pp.790-798, 2005.

J. F. Cryan and T. G. Dinan, Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour, Nat. Rev. Neurosci, vol.13, pp.701-712, 2012.

J. F. Cryan and T. G. Dinan, More than a Gut Feeling: the microbiota regulates neurodevelopment and behavior, Neuropsychopharmacology, vol.40, pp.241-242, 2015.

P. S. D'aquila, P. Brain, and P. Willner, Effects of chronic mild stress on performance in behavioural tests relevant to anxiety and depression, Physiol. Behav, vol.56, pp.90316-90322, 1994.

D. J. David, B. A. Samuels, Q. Rainer, J. Wang, D. Marsteller et al., Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression, Neuron, vol.62, pp.479-493, 2009.

I. C. De-jong, E. D. Ekkel, J. A. Van-de-burgwal, E. Lambooij, S. M. Korte et al., Effects of strawbedding on physiological responses to stressors and behavior in growing pigs, Physiol. Behav, vol.64, pp.303-310, 1998.

S. Deboer, J. Garner, R. Mccain, D. Lay, S. Eicher et al., An initial investigation into the effects of isolation and enrichment on the welfare of laboratory pigs housed in the PigTurn § system, assessed using tear staining, behaviour, physiology and haematology, Anim. Welf, vol.24, pp.15-27, 2015.

J. M. Deussing, Animal models of depression, Drug Discov. Today Dis. Models, vol.3, pp.375-383, 2006.

T. G. Dinan and J. F. Cryan, Mood by microbe: towards clinical translation, Genome Med, vol.8, p.36, 2016.

T. G. Dinan, C. Stanton, and J. F. Cryan, Psychobiotics: a novel class of psychotropic, Biol. Psychiatry, vol.74, pp.720-726, 2013.

T. G. Dinan, R. M. Stilling, C. Stanton, and J. F. Cryan, Collective unconscious: how gut microbes shape human behavior, J. Psychiatr. Res, vol.63, pp.1-9, 2015.

A. Dranovsky and R. Hen, Hippocampal neurogenesis: regulation by stress and antidepressants, Biol. Psychiatry, vol.59, pp.1136-1143, 2006.

F. Dunphy-doherty, S. M. O'mahony, V. L. Peterson, O. O'sullivan, F. Crispie et al., Post-weaning social isolation of rats leads to longterm disruption of the gut microbiota-immune-brain axis, Brain Behav. Immun, vol.68, pp.261-273, 2018.

K. Dzirasa and H. E. Covington, Increasing the validity of experimental models for depression, Ann. N. Y. Acad. Sci, vol.1265, pp.36-45, 2012.

J. C. Felger and F. E. Lotrich, Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications, Neuroscience, vol.246, pp.199-229, 2013.

M. G. García, J. G. Puig, and R. J. Torres, Abnormal adenosine and dopamine receptor expression in lymphocytes of lesch-nyhan patients, Brain Behav. Immun, vol.23, pp.1125-1131, 2009.

T. Gicquel, C. Hugbart, F. Le-devehat, S. Lepage, A. Baert et al., Death related to consumption of Rauvolfia sp. powder mislabeled as Tabernanthe iboga, Forensic Sci. Int, vol.266, pp.38-42, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01398032

I. Goshen, T. Kreisel, O. Ben-menachem-zidon, T. Licht, J. Weidenfeld et al., Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression, Mol. Psychiatry, vol.13, pp.717-728, 2008.

M. K. Hamilton, G. Boudry, D. G. Lemay, and H. E. Raybould, Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent, Am. J. Physiol. Gastrointest. Liver Physiol, vol.308, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01409505

S. S. Hasan, A. M. Clavarino, A. A. Mamun, and T. Kairuz, Incidence and risk of diabetes mellitus associated with depressive symptoms in adults: evidence from longitudinal studies, Diabetes Metab. Syndr. Clin. Res. Rev, vol.8, pp.82-87, 2014.

S. N. Heinritz, R. Mosenthin, and E. Weiss, Use of pigs as a potential model for research into dietary modulation of the human gut microbiota, Nutr. Res. Rev, vol.26, pp.191-209, 2013.

M. S. Herskin and K. H. Jensen, Effects of Different Degrees of Social Isolation on the Behaviour of Weaned Piglets Kept for Experimental Purposes, 2000.

J. J. Joseph and S. H. Golden, Cortisol dysregulation: the bidirectional link between stress, depression, and type 2 diabetes mellitus, Ann. N. Y. Acad. Sci, vol.1391, pp.20-34, 2017.

J. P. Jouany, B. Zainab, J. Senaud, C. A. Groliere, J. Grain et al., Rôle of the rumen ciliate protozoa Polyplastron multivesiculatum, Entodinium sp. and isotricha prostoma in the digestion of a mixed diet in sheep, Reprod. Nutr. Dév, vol.21, pp.871-884, 1981.

P. J. Kennedy, G. Clarke, E. M. Quigley, J. A. Groeger, T. G. Dinan et al., Gut memories: towards a cognitive neurobiology of irritable bowel syndrome, Neurosci. Biobehav. Rev, vol.36, pp.310-340, 2012.

K. G. Kjelstrup, F. A. Tuvnes, H. Steffenach, R. Murison, E. I. Moser et al., Reduced fear expression after lesions of the ventral hippocampus, Proc. Natl. Acad. Sci. 99, 2002.

A. Koh, F. De-vadder, P. Kovatcheva-datchary, and F. Bäckhed, From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites, Cell, vol.165, pp.1332-1345, 2016.

N. Kokras and C. Dalla, Preclinical sex differences in depression and antidepressant response: implications for clinical research, J. Neurosci. Res, vol.95, pp.731-736, 2017.

T. Kreisel, M. G. Frank, T. Licht, R. Reshef, O. Ben-menachem-zidon et al., Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis, Mol. Psychiatry, vol.19, pp.699-709, 2014.

M. D. Kvarta, K. E. Bradbrook, H. M. Dantrassy, A. M. Bailey, and S. M. Thompson, Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses, J. Neurophysiol, vol.114, pp.1713-1724, 2015.

J. M. Lackner, B. M. Quigley, and E. B. Blanchard, Depression and abdominal pain in ibs patients: the mediating role of catastrophizing, Psychosom. Med, vol.66, pp.435-441, 2004.

R. G. Lafrance-corey and C. L. Howe, Isolation of brain-infiltrating leukocytes, J. Vis. Exp, vol.52, p.2747, 2011.

M. Lemaire, S. Dou, A. Cahu, M. Formal, L. Le-normand et al., Addition of dairy lipids and probiotic Lactobacillus fermentum in infant formula programs gut microbiota and entero-insular axis in adult minipigs, Sci. Rep, vol.8, p.11656, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01858523

B. E. Leonard, Inflammation and depression: a causal or coincidental link to the pathophysiology?, Acta Neuropsychiatr, vol.30, pp.1-16, 2018.

N. M. Lind, A. Moustgaard, J. Jelsing, G. Vajta, P. Cumming et al., The use of pigs in neuroscience: modeling brain disorders, Neurosci. Biobehav. Rev, vol.31, pp.728-751, 2007.

M. Maes, M. Kubera, J. Leunis, B. , and M. , Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut, J. Affect. Disord, vol.141, pp.55-62, 2012.

Y. S. Mineur, C. Belzung, and W. E. Crusio, Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice, Behav. Brain Res, vol.175, pp.43-50, 2006.

R. D. Moloney, A. C. Johnson, S. M. O'mahony, T. G. Dinan, B. Greenwood-van-meerveld et al., Stress and the microbiota-gut-brain axis in visceral pain: relevance to irritable bowel syndrome, CNS Neurosci. Ther, vol.22, pp.102-117, 2016.

C. Nasca, D. Zelli, B. Bigio, S. Piccinin, S. Scaccianoce et al., Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity, Proc. Natl. Acad. Sci, vol.112, pp.14960-14965, 2015.

X. Pang, X. Hua, Q. Yang, D. Ding, C. Che et al., Inter-species transplantation of gut microbiota from human to pigs, ISME J, vol.1, pp.156-162, 2007.

B. Pflug, R. Erikson, J. , and A. , Depression and daily temperature, Acta Psychiatr. Scand, vol.54, pp.254-266, 1976.

R. Poletto, H. Cheng, R. L. Meisel, B. T. Richert, and J. N. Marchant-forde, Gene expression of serotonin and dopamine receptors and monoamine oxidase-A in the brain of dominant and subordinate pubertal domestic pigs (Sus scrofa) fed a ?-adrenoreceptor agonist, Brain Res, vol.1381, 2011.

R. D. Porsolt, A. Bertin, J. , and M. , Behavioral despair in mice: a primary screening test for antidepressants, Arch. Int. Pharmacodyn. Ther, vol.229, pp.327-336, 1977.

H. H. Pothuizen, W. Zhang, A. L. Jongen-rêlo, J. Feldon, Y. et al., Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within-subject, withintask comparison of reference and working spatial memory, Eur. J. Neurosci, vol.19, pp.705-712, 2004.

S. W. Provencher, Estimation of metabolite concentrations from localized in vivo proton NMR spectra, Magn. Reson. Med, vol.30, pp.672-679, 1993.

G. Quesseveur, D. J. David, M. C. Gaillard, P. Pla, M. V. Wu et al., BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities, Transl. Psychiatry, vol.3, p.253, 2013.

K. Ramirez, J. Fornaguera-trías, and J. F. Sheridan, Stress-induced microglia activation and monocyte trafficking to the brain underlie the development of anxiety and depression, Inflammation-Associated Depression: Evidence, Mechanisms and Implications, pp.155-172, 2016.

J. L. Rausch, M. E. Johnson, K. M. Corley, H. M. Hobby, N. Shendarkar et al., Depressed patients have higher body temperature: 5-HT transporter long promoter region effects, Neuropsychobiology, vol.47, pp.120-127, 2003.

I. Reimert, J. E. Bolhuis, B. Kemp, and T. B. Rodenburg, Indicators of positive and negative emotions and emotional contagion in pigs, Physiol. Behav, vol.109, pp.42-50, 2013.

G. Richter-levin and L. Xu, How could stress lead to major depressive disorder? IBRO Rep, vol.4, pp.38-43, 2018.

N. Rohleder, Stimulation of Systemic Low-Grade Inflammation by Psychosocial Stress, Psychosom. Med, vol.76, p.181, 2014.

E. Roura, S. Koopmans, J. Lallès, L. Huerou-luron, I. De-jager et al., Critical review evaluating the pig as a model for human nutritional physiology, Nutr. Res. Rev, vol.29, pp.60-90, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01527066

T. M. Rudkin, A. , and D. L. , Proton magnetic resonance spectroscopy for the diagnosis and management of cerebral disorders, Arch. Neurol, vol.56, pp.919-926, 1999.

M. A. Ruis, J. H. Te-brake, B. Engel, W. G. Buist, H. J. Blokhuis et al., Adaptation to social isolation: acute and long-term stress responses of growing gilts with different coping characteristics, Physiol. Behav, vol.73, pp.541-551, 2001.

M. A. Ruis, J. H. Te-brake, B. Engel, E. D. Ekkel, W. G. Buist et al., The circadian rhythm of salivary cortisol in growing pigs: effects of age. Gender Stress, Physiol. Behav, vol.62, issue.97, pp.177-184, 1997.

S. Saikali, P. Meurice, P. Sauleau, P. Eliat, P. Bellaud et al., A three-dimensional digital segmented and deformable brain atlas of the domestic pig, J. Neurosci. Methods, vol.192, pp.102-109, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01133910

L. Santarelli, M. Saxe, C. Gross, A. Surget, F. Battaglia et al., Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants, Science, vol.301, pp.805-809, 2003.

R. M. Sapolsky, Individual differences and the stress response, Semin. Neurosci, vol.6, pp.261-269, 1994.

A. Sarkar, S. M. Lehto, S. Harty, T. G. Dinan, J. F. Cryan et al., Psychobiotics and the manipulation of bacteria-gut-brain signals, Trends Neurosci, vol.39, pp.763-781, 2016.

J. Savitz, I. Lucki, and W. C. Drevets, 5-HT1A receptor function in major depressive disorder, Prog. Neurobiol, vol.88, pp.17-31, 2009.

L. Schrader and J. Ladewig, Temporal differences in the responses of the pituitary adrenocortical axis, the sympathoadrenomedullar axis, heart rate, and behaviour to a daily repeated stressor in domestic pigs, Physiol. Behav, vol.66, pp.775-783, 1999.

M. L. Seibenhener and M. C. Wooten, Use of the open field maze to measure locomotor and anxiety-like behavior in mice, J. Vis. Exp, vol.6, p.52434, 2015.

L. B. Shomaker, M. Tanofsky-kraff, E. A. Stern, R. Miller, J. M. Zocca et al., Longitudinal study of depressive symptoms and progression of insulin resistance in youth at-risk for adult obesity, Diabetes Care, vol.34, pp.2458-2463, 2011.

Y. Song, J. E. Manson, L. Tinker, B. V. Howard, L. H. Kuller et al., Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the women's health initiative observational study, Diabetes Care, vol.30, pp.1747-1752, 2007.

L. Steru, R. Chermat, B. Thierry, and P. Simon, The tail suspension test: a new method for screening antidepressants in mice, Psychopharmacology, vol.85, pp.367-370, 1985.

Q. Tang, X. Li, P. Song, and L. Xu, Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and prediabetes screening: developments in research and prospects for the future, Drug Discov. Ther, vol.9, pp.380-385, 2015.

M. A. Taylor and M. Fink, Restoring melancholia in the classification of mood disorders, J. Affect. Disord, vol.105, pp.1-14, 2008.

M. T. Treadway and D. H. Zald, Reconsidering anhedonia in depression: lessons from translational neuroscience, Neurosci. Biobehav. Rev, vol.35, pp.537-555, 2011.

D. Val-laillet, M. Besson, S. Guérin, N. Coquery, G. Randuineau et al., A maternal Western diet during gestation and lactation modifies offspring's microbiota activity, blood lipid levels, cognitive responses, and hippocampal neurogenesis in Yucatan pigs, FASEB J, vol.31, pp.2037-2049, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01484170

D. Val-laillet, S. Guérin, N. Coquery, I. Nogret, M. Formal et al., Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs, FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol, vol.32, pp.2160-2171, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01771621

D. Val-laillet, P. Meurice, and C. Clouard, Familiarity to a feed additive modulates its effects on brain responses in reward and memory regions in the pig model, PLoS One, vol.11, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01413510

M. Valles-colomer, G. Falony, Y. Darzi, E. F. Tigchelaar, J. Wang et al., The neuroactive potential of the human gut microbiota in quality of life and depression, Nat. Microbiol, vol.4, pp.623-632, 2019.

P. Vodi?ka, K. Smetana, B. Dvoøánková, T. Emerick, Y. Z. Xu et al., The miniature pig as an animal model in biomedical research, Ann. N. Y. Acad. Sci, vol.1049, pp.161-171, 2005.

N. Vogelzangs, K. Suthers, L. Ferrucci, E. M. Simonsick, A. Ble et al., Hypercortisolemic depression is associated with the metabolic syndrome in late-life, Psychoneuroendocrinology, vol.32, pp.151-159, 2007.

P. Willner, The chronic mild stress (CMS) model of depression: history, evaluation and usage, Neurobiol. Stress, vol.6, pp.78-93, 2017.

M. P. Witter, P. A. Naber, T. Haeften, W. C. Machielsen, S. A. Rombouts et al., Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways, Hippocampus, vol.10, pp.398-410, 2000.

E. S. Wohleb and J. Delpech, Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences, Prog. Neuropsychopharmacol. Biol. Psychiatry, vol.79, pp.40-48, 2017.

G. Wolf, T. Lifschytz, H. Ben-ari, P. Tatarskyy, T. K. Merzel et al., Effect of chronic unpredictable stress on mice with developmental under-expression of the Ahi1 gene: behavioral manifestations and neurobiological correlates, Transl. Psychiatry, vol.8, p.124, 2018.

, Depression: Let's Talk" Says WHO, as Depression Tops List of Causes of ill Health, 2017.

, Gender and Women's Mental health WHO, 2019.

Y. Xia, Y. Fu, H. Xu, J. Guan, H. Yi et al., Changes in cerebral metabolites in obstructive sleep apnea: a systemic review and meta-analysis, Sci. Rep, vol.6, p.28712, 2016.

L. Yang, Y. Zhao, Y. Wang, L. Liu, X. Zhang et al., The effects of psychological stress on depression, Curr. Neuropharmacol, vol.13, pp.494-504, 2015.

A. Zalli, O. Jovanova, W. J. Hoogendijk, H. Tiemeier, and L. A. Carvalho, Low-grade inflammation predicts persistence of depressive symptoms, Psychopharmacology, vol.233, pp.1669-1678, 2016.

Y. Zhang, F. Gu, J. Chen, D. , and W. , Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat, Brain Res, vol.1366, pp.141-148, 2010.

M. J. Zielinski, J. C. Veilleux, E. S. Winer, and M. R. Nadorff, A shortterm longitudinal examination of the relations between depression, anhedonia, and self-injurious thoughts and behaviors in adults with a history of self-injury, Compr. Psychiatry, vol.73, pp.187-195, 2017.