Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry

Carolina Baeza-Velasco (1, 2) , Guillem Pailhez , Antonio Bulbena , Amaria Baghdadli (1, 3)

1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 UPD5 Psychologie - Université Paris Descartes – Institut de psychologie
3 EPSYLON - Dynamique des capacités humaines et des conduites de santé

The heritable disorders of connective tissue (HDCTs) are a group of genetic disorders affecting connective tissue matrix proteins. Fragility, laxity of tissues and joint hypermobility (JH) are commons features of HDCT for which the prognosis may range from benign to life threatening. JH and HDCTs, especially joint hypermobility syndrome, Ehlers-Danlos syndromes and Marfan syndrome, have been associated with psychiatric symptomatology. We explored the existing knowledge concerning this association in order to provide an overview of mental disorders linked to JH/HDCT, as well as the hypotheses proposed to explain such association.

Mots clés: Ehlers–Danlos; Hereditary disorders of the connective tissue; Joint hypermobility; Marfan; Psychiatric disorders

Domaines: Psychiatrie et santé mentale

Carolina Baeza-Velasco, Guillem Pailhez, Antonio Bulbena, Amaria Baghdadli. Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry. General Hospital Psychiatry, 2015, 37 (1), pp.24-30. ⟨10.1016/j.genhosppsych.2014.10.002⟩. ⟨hal-02164807⟩