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The molecular machinery of regulated cell death

Abstract : Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.
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Submitted on : Friday, May 10, 2019 - 10:07:58 AM
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Daolin Tang, Rui Kang, Tom Berghe, Peter Vandenabeele, Guido Kroemer. The molecular machinery of regulated cell death. Cell Research, Nature Publishing Group, 2019, 29 (5), pp.347-364. ⟨10.1038/s41422-019-0164-5⟩. ⟨hal-02125072⟩

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