Efficient red light photo-uncaging of active molecules in water upon assembly into nanoparticles

Abstract : We introduce a means of efficiently photo-uncaging active compounds from amino-1,4-benzoquinone in aqueous environments. Aqueous photochemistry of this photocage with one-photon red light is typically not efficient unless the photocaged molecules are allowed to assemble into nanoparticles. A variety of biologically active molecules were functionalized with the photocage and subsequently formulated into water-dispersible nanoparticles. Red light irradiation through various mammalian tissues achieved efficient photo-uncaging. Co-encapsulation of NIR fluorescent dyes and subsequent photomodulation provides a NIR fluorescent tool to assess both particle location and successful photorelease.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02111719
Contributor : Laëtitia Legoupil <>
Submitted on : Friday, April 26, 2019 - 11:07:31 AM
Last modification on : Wednesday, August 7, 2019 - 12:18:06 PM

Links full text

Identifiers

Citation

Carl-Johan Carling, Jason Olejniczak, Alexandra Foucault-Collet, Guillaume Collet, Mathieu Viger, et al.. Efficient red light photo-uncaging of active molecules in water upon assembly into nanoparticles. Chemical Science , The Royal Society of Chemistry, 2016, 7 (3), pp.2392-2398. ⟨10.1039/c5sc03717d⟩. ⟨hal-02111719⟩

Share

Metrics

Record views

11