Rotaxanes of Cyclic Peptides

Vincent Aucagne (1) , David Leigh , Julia Lock , Andrew Thomson

1 School of Chemistry, University of Edinburgh

The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.

Domaines: Sciences du Vivant [q-bio]

Vincent Aucagne, David Leigh, Julia Lock, Andrew Thomson. Rotaxanes of Cyclic Peptides. Journal of the American Chemical Society, 2006, 128 (6), pp.1784-1785. ⟨10.1021/ja057206q⟩. ⟨hal-02086005⟩