The MMP2 Rs243865-T Allele Is Not a Major Genetic Factor for Rheumatoid Arthritis in the French Caucasian Population

Laurent Jacq (1) , Vitor Hugo Teixeira (1) , Sophie Garnier (1) , Elisabeth Petit-Teixeira (1) , François Cornélis (1)

1 GenHotel - Laboratoire de recherche européen pour la polyarthrite rhumatoïde

The MMP2 rs243865-T allele was recently suggested to be associated with rheumatoid arthritis (RA) in a case-control study. MMP2 is a positional RA candidate gene. Our aim was to test rs243865 in a French family based study. No significant result was shown. The MMP2 rs243865-T allele is not a major rheumatoid arthritis genetic factor in this population.

Mots clés: Arthritis; Female; Genetic Predisposition to Disease; Humans; Male; Rheumatoid; European Continental Ancestry Group; Alleles; France; Matrix Metalloproteinase 2

Domaines: Génétique humaine

Laurent Jacq, Vitor Hugo Teixeira, Sophie Garnier, Elisabeth Petit-Teixeira, François Cornélis. The MMP2 Rs243865-T Allele Is Not a Major Genetic Factor for Rheumatoid Arthritis in the French Caucasian Population. International Journal of Immunogenetics, 2008, 35 (2), pp.97--99. ⟨10.1111/j.1744-313X.2007.00740.x⟩. ⟨hal-02084390⟩