Occupational exposure to organic solvents and risk of male breast cancer: a European multicenter case-control study

Nasser Laoulali , Corinne Pilorget (1) , Diane Cyr (2) , Monica Neri (3) , Linda Kaerlev (4) , Svend Sabroe (5) , Giuseppe Gorini (6) , Lorenzo Richiardi (7) , Maria Morales-Suarez-Varela (8) , Agustin Llopis-Gonzalez (9) , Wolfgang Ahrens (10) , Karl-Heinz Jockel (11) , Noemia Afonso (12) , Mikael Eriksson (13) , Eriksson Merletti , Jørn Olsen , Elsebeth Lynge (14) , Pascal Guenel (3)

1 UMRESTTE UMR T9405 - Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement
2 Population-based Epidemiologic Cohorts Unit, Inserm, Villejuif, France
3 CESP - Centre de recherche en épidémiologie et santé des populations
4 SDU - University of Southern Denmark
5 Aarhus University [Aarhus]
6 Occupational & Environmental Epidemiology Section, Cancer Research & Prevention Institute (ISPO), Florence, Italy
7 DMS - Department of Medical Sciences [Turin, Italy]
8 Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Burjassot, Valencia, Spain
9 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
10 Institute for Prevention Research and Epidemiology; BIPS-Institute for Epidemiology and Prevention Research GmbH, Bremen, Germany
11 Institute for Medical Informatics, Biometry and Epidemiology
12 Centro Hospitalar do Porto, Porto, Portugal
13 Skane University Hospital [Lund]
14 Department of Public Health, University of Copenhagen, Copenhagen, Denmark

The etiology of male breast cancer (MBC) is largely unknown but a causal role of exposure to organic solvents has been suggested. Previous studies on occupational risk factors of breast cancer were often restricted to women who are frequently exposed to lower levels and at a lower frequency than men. We investigated the association between MBC and occupational exposure to petroleum and oxygenated and chlorinated solvents in a multicenter case-control study of rare cancers in Europe. METHODS: The study included 104 MBC cases and 1901 controls. Detailed lifetime work history was obtained during interviews, together with sociodemographic characteristics, medical history and lifestyle factors. Occupational exposures to solvents were estimated from a job-exposure matrix. Odds ratios (OR) and their 95% confidence intervals (CI) were calculated using unconditional logistic regression models. RESULTS: Lifetime cumulative exposure to trichloroethylene >23.9 ppm years was associated with an increased MBC risk, compared to non-exposure [OR (95% CI): 2.1 (1.2-4.0); P trend

Mots clés: ALCOHOLIC SOLVENT; BENZENE; BREAST CANCER; CASE-CONTROL STUDY; CHLORINATED SOLVENT; ETHYLENE GLYCOL; EUROPEAN; JEM; JOB-EXPOSURE MATRIX; MALE BREAST CANCER; MULTICENTER CASE-CONTROL STUDY; OCCUPATIONAL EXPOSURE; ORGANIC SOLVENT; PETROLEUM SOLVENT; TRICHLOROETHYLENE

Domaines: Santé publique et épidémiologie

Nasser Laoulali, Corinne Pilorget, Diane Cyr, Monica Neri, Linda Kaerlev, et al.. Occupational exposure to organic solvents and risk of male breast cancer: a European multicenter case-control study. Scandinavian Journal of Work, Environment and Health, 2018, 44 (3), pp. 310-322. ⟨10.5271/sjweh.3717⟩. ⟨hal-02051513⟩