Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013-2016

Lorenzo Subissi , Timothee Dub , Marianne Besnard , Teheipuaura Mariteragi-Helle , Tuxuan Nhan , Delphine Lutringer-Magnin , Philippe Barboza , Celine Gurry , Pauline Brindel , Eric J. Nilles , David Baud , Angela Merianos , Didier Musso (1) , Judith R. Glynn , Gilles Dupuis , Van-Mai Cao-Lormeau (1) , Marine Giard , Henri-Pierre Mallet

1 VITROME - Vecteurs - Infections tropicales et méditerranéennes

Congenital Zika virus syndrome consists of a large spectrum of neurologic abnormalities seen in infants infected with Zika virus in utero. However, little is known about the effects of Zika virus intrauterine infection on the neurocognitive development of children born without birth defects. Using a case-control study design, we investigated the temporal association of a cluster of congenital defects with Zika virus infection. In a nested study, we also assessed the early childhood development of children recruited in the initial study as controls who were born without known birth defects,. We found evidence for an association of congenital defects with both maternal Zika virus seropositivity (time of infection unknown) and symptomatic Zika virus infection during pregnancy. Although the early childhood development assessment found no excess burden of developmental delay associated with maternal Zika virus infection, larger, longer-term studies are needed.

Domaines: Maladies infectieuses

Lorenzo Subissi, Timothee Dub, Marianne Besnard, Teheipuaura Mariteragi-Helle, Tuxuan Nhan, et al.. Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013-2016. Emerging Infectious Diseases, 2018, 24 (10), pp.1850-1858. ⟨10.3201/eid2410.172079⟩. ⟨hal-02004011⟩