Development of a freeze-dried kit formulation for the preparation of 99m Tc-NTP 15-5, a radiotracer for scintigraphic imaging of proteoglycans

Abstract : The cartilage-targeting strategy is based on the strong affinity of quaternary ammonium (QA) functions for cartilage proteoglycans. We use a bifunctional agent containing QA moiety and a polyazamacrocycle structure able to complex technetium-99m. (99m)Tc-NTP 15-5 was selected for its high stability and its high affinity for proteoglycans in vivo. Labeling conditions of NTP 15-5 were optimized, and a lyophilized kit was developed for radiolabeling of (99m)Tc-NTP 15-5 (radiochemical yields 94.6±1.8%). (99m)Tc-NTP 15-5 was stable and resulted in favorable biological evaluations.
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https://hal.archives-ouvertes.fr/hal-01961372
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Submitted on : Wednesday, December 19, 2018 - 7:43:21 PM
Last modification on : Thursday, December 20, 2018 - 1:26:11 AM

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Aurélien Vidal, Vincent Gaumet, Marie-Josephe Galmier, Sophie Besse, Fernand Leal, et al.. Development of a freeze-dried kit formulation for the preparation of 99m Tc-NTP 15-5, a radiotracer for scintigraphic imaging of proteoglycans. Applied Radiation and Isotopes, Elsevier, 2015, 101, pp.1-9. ⟨10.1016/j.apradiso.2015.03.010⟩. ⟨hal-01961372⟩

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