Metabolic risk factors in young adults infected with HIV since childhood compared with the general population

Elise Arrivé (1, 2, 3) , Jean-Paul Viard (4, 5, 6, 7) , Benoît Salanave (8, 9) , Catherine Dollfus (10) , Sophie Matheron (11) , Véronique Reliquet (12) , Elisa Arezes (1) , Laura Nailler (1) , Corinne Vigouroux (13, 14, 15) , Josiane Warszawski (16, 1, 17)

1 CESP - Centre de recherche en épidémiologie et santé des populations
2 CHU Bordeaux
3 BPH - Bordeaux population health
4 Centre de Diagnostic et de Thérapeutique, Hôpital de l’Hôtel-Dieu [Paris]
5 EA 7327 - Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV)
6 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
7 UPD5 - Université Paris Descartes - Paris 5
8 USEN - Unité de Surveillance et d'Epidémiologie Nutritionnelle
9 CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
10 CHU Trousseau [APHP]
11 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
12 Service des maladies infectieuses et tropicales [CHU Nantes]
13 UMRS893 - Centre de Recherche Saint-Antoine
14 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
15 CHU Saint-Antoine [AP-HP]
16 UP11 - Université Paris-Sud - Paris 11
17 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]

AIM: Metabolic risk factors are poorly documented for the first generation of young adults who have lived with HIV since childhood. We compared their metabolic profile with that of adults of same age from the general population. METHODS: We conducted a cross-sectional analysis of data from two populations: (1) COVERTE (ANRS-CO19), a French national cohort of 18 to 30-year-old patients HIV-infected since childhood, and (2) ENNS, a national cross-sectional population-based household survey on nutrition. Body mass index (BMI), blood pressure, waist circumference, fasting glucose, triglycerides, and HDL-, LDL- and total cholesterol were measured in both studies. Direct standardization on overweight and education level and logistic regression were used to compare the prevalence of metabolic abnormalities between the two populations. RESULTS: Data from 268 patients from COVERTE and 245 subjects from ENNS were analyzed. Tobacco use was similar in both groups. HIV-infected patients had increased mean waist-to-hip ratio and triglycerides to HDL-cholesterol ratio and decreased mean HDL-cholesterol as compared to their counterparts from the general population in both genders. In HIV-infected patients, metabolic syndrome was identified in 13.2% of men (95% confidence interval [CI]: 7.1-19.2) and 10.4% (95% CI: 5.4-15.3) of women versus 10.6% (95%CI: 1.5-19.7) and 1.7% (95%CI: 0-4.1) in subjects from the general population, respectively. CONCLUSION: Young adults infected with HIV since childhood had a higher prevalence of dyslipidemia and metabolically detrimental fat distribution than adults of same age of the general population, supporting close monitoring for cardiometabolic diseases.

Domaines: Sciences du Vivant [q-bio]; Santé publique et épidémiologie

Elise Arrivé, Jean-Paul Viard, Benoît Salanave, Catherine Dollfus, Sophie Matheron, et al.. Metabolic risk factors in young adults infected with HIV since childhood compared with the general population. PLoS ONE, 2018, 13 (11), pp.e0206745. ⟨10.1371/journal.pone.0206745⟩. ⟨hal-01943988⟩