Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Thirumala-Devi Kanneganti (1) , Nesrin Özören , Mathilde Body-Malapel (2) , Amal Amer , Jong-Hwan Park , Luigi Franchi (3) , Joel Whitfield , Winfried Barchet , Marco Colonna (4) , Peter Vandenabeele (5) , John Bertin (6) , Anthony Coyle (6) , Ethan Grant (7) , Shizuo Akira (8) , Gabriel Nuñez (9)

1 St Jude Children's Research Hospital
2 Physiopathologie des Maladies Inflammatoires de l'Intestin
3 School of Biochemistry and Immunology
4 Department of Immunology
5 Department for Molecular Biomedical Research
6 Millennium Pharmaceuticals
7 Interactions récepteurs ligands en immunocancérologie et immunopathologie
8 Department of Host Defense
9 University of Michigan Medical School [Ann Arbor]

Domaines: Sciences du Vivant [q-bio]; Immunologie

Thirumala-Devi Kanneganti, Nesrin Özören, Mathilde Body-Malapel, Amal Amer, Jong-Hwan Park, et al.. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature, 2006, 440 (7081), pp.233 - 236. ⟨10.1038/nature04517⟩. ⟨hal-01936406⟩