Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies

M. M. Ulaszewska 1 C. H. Weinert 2 A. Trimigno 3 R. Portmann 4 C. Andres Lacueva 5, 6, 7, 8 R. Badertscher 4 L. Brennan 9, 10 C. Brunius 11 A. Bub 12 F. Capozzi 3 M. Cialie Rosso 13 C. E. Cordero 13 H. Daniel 14 Stéphanie Durand 15, 16 B. Egert 2 P. G. Ferrario 3 E. J. M. Feskens 17 P. Franceschi 18 M. Garcia-Aloy 5, 6, 7, 8 Franck Giacomoni 15, 16 P. Giesbertz 19 R. Gonzalez-Dominguez 5, 6, 7, 8 K. Hanhineva 20, 21 L. Y. Hemeryck 22, 23 J. Kopka 24 S. E. Kulling 2 R. Llorach 5, 6, 7, 8 Claudine Manach 15 F. Mattivi 1, 25, 26 Carole Migné 15, 16 L. H. Munger 27 B. Ott 28, 29, 30 G. Picone 3 G. Pimentel 27 Estelle Pujos-Guillot 15, 16 S. Riccadonna 18 M. J. Rist 3 C. Rombouts 22, 23 J. Rubert 1 T. Skurk 28, 29, 30 P. S. C. Sri Harsha 9, 10 L. van Meulebroek 22, 23 L. Vanhaecke 22, 23 R. Vazquez-Fresno 31 D. Wishart 31 G. Vergeres 27
Abstract : The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful "tips and tricks" along the analytical workflow.
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M. M. Ulaszewska, C. H. Weinert, A. Trimigno, R. Portmann, C. Andres Lacueva, et al.. Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies. Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2018, [Epub ahead of print], pp.e1800384. ⟨10.1002/mnfr.201800384⟩. ⟨hal-01906543⟩



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