In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8

Dimitri Renard (1) , Laurent Collombier (1) , Christel Castelli (2, 3) , Jean-Pierre Pouget (1, 4) , Pierre-Olivier Kotzki (1, 4) , Vincent Boudousq (1, 4)

1 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
2 BESPIM
3 AIDMP - Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415
4 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier

BACKGROUND: In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correlation between CTG-numbers and FDG-PET. METHODS: FDG-PET was performed in 24 patients and compared to 24 controls. Pearson's correlation was used to analyse correlation. RESULTS: SPM8 revealed Brodmann area 8 as the area with the most severe reduced FDG-uptake. Weak, although not statistically significant, correlation was observed between CTG-numbers and reduced FDG-uptake in Brodmann area 8. CONCLUSION: In DM1, Brodmann area 8 is the area with the most severe reduced FDG-uptake on FDG-PET. Brodmann area 8 reduced FDG-uptake is correlated -although weakly- to CTG-repeat numbers.

Domaines: Neurosciences [q-bio.NC]; Médecine humaine et pathologie

Dimitri Renard, Laurent Collombier, Christel Castelli, Jean-Pierre Pouget, Pierre-Olivier Kotzki, et al.. In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8. BMC Neurology, 2016, 16, pp.100. ⟨10.1186/s12883-016-0630-3⟩. ⟨hal-01903834⟩