Epigenetic dynamic during endochondral ossification and articular cartilage development

Lyess Allas (1) , Karim Boumediene (1) , Catherine Baugé (1)

1 BioConnecT - Biotechnologie des tissus conjonctifs et cutanés / Biology of Connective and Cutaneous Tissues

Within the last decade epigenetics has emerged as fundamental regulator of numerous cellular processes, including those orchestrating embryonic and fetal development. As such, epigenetic factors play especially crucial roles in endochondral ossification, the process by which bone tissue is created, as well during articular cartilage formation. In this review, we summarize the recent discoveries that characterize how DNA methylation, histone post-translational modifications and non-coding RNA (e.g., miRNA and lcnRNA) epigenetically regulate endochondral ossification and chondrogenesis.

Mots clés: Methylation; Bone; Joint; Cartilage; Development biology; ADN; Histone; Endochondral ossification; Osteoarthritis; Epigenetic

Domaines: Sciences du Vivant [q-bio]; Rhumatologie et système ostéo-articulaire

Lyess Allas, Karim Boumediene, Catherine Baugé. Epigenetic dynamic during endochondral ossification and articular cartilage development. BONE, 2018, pp.523-532. ⟨10.1016/j.bone.2018.10.004⟩. ⟨hal-01898175⟩