[Allergy to neuromuscular blocking agents].

Allergie et curares

Anca Mirela Chiriac (1, 2) , Pascal Demoly (1, 2)

1 Département pneumologie et addictologie [Montpellier]
2 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique

Allergy to neuromuscular blocking agents (NMBAs) has been the first cause of perioperative anaphylaxis for decades, in most countries. The most frequently involved agents are suxamethonium and rocuronium. The allergy work-up is compulsory to demonstrate or rule out allergy to NMBAs, if there is a compatible clinical history. Doing otherwise exposes the patient to death if the same or related NMBA is re-injected. In cases of true allergy, assessing cross-reactivity to other NMBAs is mandatory. The cross-sensitization hypothesis is presently being investigated and if confirmed, it could allow primary prevention measures to be implemented.

Domaines: Médecine humaine et pathologie

Anca Mirela Chiriac, Pascal Demoly. Allergie et curares. La Presse Médicale, 2016, 45 (9), pp.768 - 773. ⟨10.1016/j.lpm.2016.02.023⟩. ⟨hal-01867857⟩