Multimerized IgG1 Fc molecule as an anti-inflammatory agent

Emmanuel Stephen-Victor (1) , Jagadeesh J Bayry (2, 3)

1 Boston Children's Hospital
2 USPC - Université Sorbonne Paris Cité
3 CRC - Centre de Recherche des Cordeliers

The success of intravenous immunoglobulin immunotherapy in autoimmune diseases has inspired the development of novel Fc-based therapeutics, in particular, multimerized polyvalent Fc molecules. A new study reports that a recombinant IgG1 Fc hexamer alleviates acute and chronic autoimmune diseases in mice.

Domaines: Immunothérapie

Emmanuel Stephen-Victor, Jagadeesh J Bayry. Multimerized IgG1 Fc molecule as an anti-inflammatory agent. Nature Reviews Rheumatology, 2018, 14, pp.390-392. ⟨10.1038/s41584-018-0013-9⟩. ⟨hal-01835524⟩