Induced pluripotent stem cells: An unlimited source of organs for transplantation

Abstract : Organ production outside the human body could address the shortage of organs for transplantation. However, in vitro organ production is still a faraway perspective, particularly because of the difficulty in establishing an effective vascularization. A new emerging technology proposes to use carrier animals for the development of human organs. In this approach, induced pluripotent stem cells (iPSC) are injected in animal embryos to produce chimeric animals that contain autologous human organs.
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Submitted on : Thursday, May 17, 2018 - 6:15:29 PM
Last modification on : Tuesday, May 28, 2019 - 10:42:01 AM

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John de Vos, Said Assou. Induced pluripotent stem cells: An unlimited source of organs for transplantation. Clinics and Research in Hepatology and Gastroenterology, Elsevier, 2017, 41 (3), pp.249 - 253. ⟨10.1016/j.clinre.2016.10.008⟩. ⟨hal-01794741⟩

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