Consequences of increasing convection onto patient care and protein removal in hemodialysis

Nathalie Gayrard (1, 2) , Alain Ficheux (1, 2) , Flore Duranton (1, 2) , Caroline Guzman (1, 2) , Ilan Szwarc (3) , Fernando Vetromile (3) , Chantal Cazevieille (4) , Philippe Brunet (5) , Marie-Françoise Servel (3) , Angel Argilés (1, 2, 3) , Moglie Le Quintrec (6, 7)

1 BC2M - Biocommunication en Cardio-Métabolique
2 R&D - RD-Néphrologie
3 NDSG - Néphrologie Dialyse Saint Guilhem
4 INM - Institut des Neurosciences de Montpellier
5 Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM]
6 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
7 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)

Introduction: Recent randomised controlled trials suggest that on-line hemodiafiltration (OL-HDF) improves survival, provided that it reaches high convective volumes. However, there is scant information on the feasibility and the consequences of modifying convection volumes in clinics. Methods: Twelve stable dialysis patients were treated with high-flux 1.8 m2 polysulphone dialyzers and 4 levels of convection flows (QUF) based on GKD-UF monitoring of the system, for 1 week each. The consequences on dialysis delivery (transmembrane pressure (TMP), number of alarms, % of achieved prescribed convection) and efficacy (mass removal of low and high molecular weight compounds) were analysed. Results: TMP increased exponentially with QUF (p<0.001 for N >56,000 monitoring values). Beyond 21 L/session, this resulted into frequent TMP alarms requiring nursing staff interventions (mean ± SEM: 10.3 ± 2.2 alarms per session, p<0.001 compared to lower convection volumes). Optimal convection volumes as assessed by GKD-UF-max were 20.6 ± 0.4 L/session, whilst 4 supplementary litres were obtained in the maximum situation (24.5 ± 0.6 L/session) but the proportion of sessions achieving the prescribed convection volume decreased from 94% to only 33% (p<0.001). Convection increased high molecular weight compound removal and shifted the membrane cut-off towards the higher molecular weight range. Conclusions: Reaching high convection volumes as recommended by the recent RCTs (> 20L) is feasible by setting an HDF system at its optimal conditions based upon the GKD-UF monitoring. Prescribing higher convection volumes resulted in instability of the system, provoked alarms, was bothersome for the nursing staff and the patients, rarely achieved the prescribed convection volumes and increased removal of high molecular weight compounds, notably albumin.

Domaines: Urologie et Néphrologie

Nathalie Gayrard, Alain Ficheux, Flore Duranton, Caroline Guzman, Ilan Szwarc, et al.. Consequences of increasing convection onto patient care and protein removal in hemodialysis. PLoS ONE, 2017, 12 (2), pp.e0171179. ⟨10.1371/journal.pone.0171179⟩. ⟨hal-01784358⟩