Skip to Main content Skip to Navigation
Journal articles

MRI quantitative T2* mapping on thrombus to predict recanalization after endovascular treatment for acute anterior ischemic stroke

Abstract : In anterior acute ischemic stroke (AAIS) treated with endovascular treatment (EVT), the susceptibility vessel sign (SVS+ or SVS-) is related to recanalization results (TICI 2b/3) and clinical outcome. However, a binary qualitative assessment of thrombus using SVS does not reflect its complex composition. Our aim was to assess whether a quantitative MRI marker, Thrombus-T2* relaxation time, may be assessable in clinical routine and may to predict early successful recanalization after EVT, defined as a TICI 2b/3 recanalization obtained in 2 attempts or less. MATERIAL AND METHODS: Thrombus-T2* relaxation time was prospectively obtained from consecutive AAIS patients treated by EVT (concomitant aspiration and stent retriever). Quantitative values were compared between early recanalization and late or unsuccessful recanalization. RESULTS: Thirty patients with AAIS were included and Thrombus-T2* relaxation time was obtained in all patients. Earlier TICI 2b/3 recanalization were obtained in 22 patients (73%) and was significantly associated with SVS+ (1/8 vs. 16/22, P=0.01) and a shorter Thombus-T2* relaxation time (mean SD, range: 257, 18-50ms vs. 45 9, 35-60ms, P\textless0.001). CONCLUSION: A new quantitative MRI biomarker, the Thrombus-T2* relaxation time is assessable in clinical routine. In a preliminary study of 30 patients, a shorter Thombus-T2* relaxation time is related to earlier recanalization after EVT using combination of stent retriever and aspiration.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-01761877
Contributor : Pascale Roussel <>
Submitted on : Monday, April 9, 2018 - 2:31:02 PM
Last modification on : Friday, May 15, 2020 - 12:22:05 PM

Identifiers

Collections

Citation

R. Bourcier, N. Brecheteau, V. Costalat, B. Daumas-Duport, B. Guyomarch-Delasalle, et al.. MRI quantitative T2* mapping on thrombus to predict recanalization after endovascular treatment for acute anterior ischemic stroke. Journal de Neuroradiologie / Journal of Neuroradiology, Elsevier Masson, 2017, 44 (4), pp.241--246. ⟨10.1016/j.neurad.2017.03.006⟩. ⟨hal-01761877⟩

Share

Metrics

Record views

84