Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability

Julien Buyck (1) , Patrick Plesiat (2, 3) , H. Traore , F. Vanderbist , Paul Tulkens (1) , Françoise van Bambeke (1)

1 Pharmacologie Cellulaire et Moléculaire [Brussels]
2 CNR - Centre National de Référence de la Résistance aux Antibiotiques
3 UFC - Université de Franche-Comté

Macrolides show high minimum inhibitory concentrations (MICs) against Pseudomonas aeruginosa when tested in recommended media (cation-adjusted Muller-Hinton broth [CA-MHB]). Nevertheless, azithromycin is successfully used in cystic fibrosis patients, supposedly because of "nonantibiotic effects."

Domaines: Bactériologie

Julien Buyck, Patrick Plesiat, H. Traore, F. Vanderbist, Paul Tulkens, et al.. Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability. Clinical Infectious Diseases, 2012, 55 (4), pp.534 - 542. ⟨10.1093/cid/cis473⟩. ⟨hal-01695413⟩