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Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability

Abstract : Macrolides show high minimum inhibitory concentrations (MICs) against Pseudomonas aeruginosa when tested in recommended media (cation-adjusted Muller-Hinton broth [CA-MHB]). Nevertheless, azithromycin is successfully used in cystic fibrosis patients, supposedly because of "nonantibiotic effects."
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https://hal.archives-ouvertes.fr/hal-01695413
Contributor : Isabelle Hostalier Connect in order to contact the contributor
Submitted on : Monday, January 29, 2018 - 12:21:09 PM
Last modification on : Monday, October 11, 2021 - 10:04:58 AM

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Julien Buyck, Patrick Plesiat, H. Traore, F. Vanderbist, Paul Tulkens, et al.. Increased Susceptibility of Pseudomonas aeruginosa to Macrolides and Ketolides in Eukaryotic Cell Culture Media and Biological Fluids Due to Decreased Expression of oprM and Increased Outer-Membrane Permeability. Clinical Infectious Diseases, Oxford University Press (OUP), 2012, 55 (4), pp.534 - 542. ⟨10.1093/cid/cis473⟩. ⟨hal-01695413⟩

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