Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride

Rui Li (1) , Mitchell Boyd-Moss (2, 3) , Benjamin Long (1, 4) , Anne Martel (5) , Andrew Parnell (6) , Andrew J. C. Dennison (6, 7, 5) , Colin J. Barrow (1) , David R. Nisbet (8) , Richard J. Williams (2, 3)

1 Deakin Univ, Ctr Chem & Biotechnol, Waurn Ponds, Vic, Australia
2 RMIT Univ, Sch Engn, Melbourne, Vic, Australia
3 St Vincents Hosp, Biofab3D, Melbourne, Vic, Australia
4 Federat Univ, Sch Appl & Biomed Sci, Mt Helen, Vic, Australia
5 ILL - Institut Laue-Langevin
6 Department of Physics and Astronomy [Sheffield]
7 Tech Univ Berlin, Dept Chem, D-10623 Berlin, Germany
8 Australian Natl Univ, Res Sch Engn, Lab Adv Biomat, Canberra, ACT, Australia

Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly

Domaines: Matière Molle [cond-mat.soft]

Rui Li, Mitchell Boyd-Moss, Benjamin Long, Anne Martel, Andrew Parnell, et al.. Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride. Scientific Reports, 2017, 7, 8 p. ⟨10.1038/s41598-017-04643-3⟩. ⟨hal-01691870⟩