Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors

Maria John Roberto Salgado 1 Thomas Gevaert Prudence A Russell Tom John Bibhusal Thapa Michael Christie Koen Van de Vijver M V Estrada Paula I Gonzalez-Ericsson Melinda Sanders Benjamin Solomon 2 Cinzia Solinas Gert G G M Van den Eynden Yves Allory 3 Matthias Preusser Johannes Hainfellner Giancarlo Pruneri 4 Andre Vingiani Sandra Demaria Fraser Symmans Paolo Nuciforo 5 Laura Comerma E A Thompson Sunil Lakhani Seong-Rim Kim Stuart Schnitt Cecile Colpaert Christos Sotiriou 1 Stefan Scherer 6 Michail Ignatiadis 7 Sunil Badve Robert H Pierce Giuseppe Viale 8 Nicolas Sirtaine Fred Penault-Llorca 9, 10 Tomohagu Sugie Susan Fineberg Soonmyung Paik Ashok Srinivasan Andre Richardson Yihong Wang Ewa Chmielik Jane Brock Douglas B Johnson Justin Balko Stephan Wienert Veerle Bossuyt Stefan Michiels 11 Nils Ternès 12 Nicole Burchardi Stephen Luen Peter Savas Fred Klauschen Peter H Watson Brad H Nelson 13 Carmen Criscitiello Sandra O'Toole Denis Larsimont 14 Roland de Wind Giuseppe Curigliano 15 Fabrice André 16 Magali Lacroix-Triki 17 Mark Van de Vijver Federico Rojo Giuseppe Floris Shahinaz Bedri Joseph Sparano David Rimm Torsten Nielsen Zuzana Kos Stephen Hewitt Baljit Singh Gelareh Farshid Sibylle Loi Kimberly H Allison Nadine Tung Sylvia Adams Karen Willard-Gallo Hugo M Horlings Leena Gandhi Andre Moreira 18 Fred Hirsch 19 Maria Dieci Maria Urbanowicz Iva Brcic Konstanty Korski Fabien Gaire Hartmut Koeppen Amy Lo Jennifer Giltnane Marlon C Rebelatto Keith E Steele Jiping Zha Kenneth Emancipator Jonathan W Juco Carsten Denkert 20 Jorge Reis-Filho 21 Sherene Loi 1 Stephen B Fox Shona Hendry Prudence A. Russell M.V. Estrada Paula I. Gonzalez-Ericsson Gert G.G.M. Van den Eynden E.A. Thompson Robert H. Pierce 22 Douglas B. Johnson 23 Peter H. Watson Brad H. Nelson Sandra O’toole Kimberly H. Allison Hugo M. Horlings Marlon C. Rebelatto Keith E. Steele Jonathan W. Juco Stephen B. Fox 24
Abstract : Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma. In part 2 of this review, we discuss the available evidence for the prognostic and predictive value of TILs in common solid tumors, including carcinomas of the lung, gastrointestinal tract, genitourinary system, gynecologic system, and head and neck, as well as primary brain tumors, mesothelioma and melanoma. The particularities and different emphases in TIL assessment in different tumor types are discussed. The standardized methodology we propose can be adapted to different tumor types and may be used as a standard against which other approaches can be compared. Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.
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Submitted on : Thursday, January 4, 2018 - 11:23:36 AM
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Maria John, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, et al.. Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors. Advances in Anatomic Pathology, Lippincott, Williams & Wilkins, 2017, 24 (6), pp.311 - 335. ⟨10.1097/PAP.0000000000000161⟩. ⟨hal-01675236⟩



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