MRI anatomical mapping and direct stereotactic targeting in the subthalamic region: functional and anatomical correspondence in Parkinson?s disease

Abstract : Object Relationships between clinical effects, anatomy, and electrophysiology are not fully understood in DBS of the subthalamic region in Parkinson's disease. We proposed an anatomic study based on direct image-guided stereotactic surgery with a multiple source data analysis. Materials and Methods A manual anatomic mapping was realized on coronal 1.5-Tesla MRI of 15 patients. Biological data were collected under local anesthesia: the spontaneous neu-ron activities and the clinical efficiency and the appearance of adverse effects. They were related to relevant current values (mA), the benefit threshold (bt, minimal current leading an clear efficiency), the adverse effect threshold (at, minimal current leading an adverse effect) and the stimulation margin (sm = at − bt); they were matched with anatomy. Results We found consistent relationships between anatomy and biological data. The optimal stimulation parameters (low bt + high sm) were noted in the dorsolateral STN. The highest spontaneous neuron activity was found in the ventromedial STN. Dorsolateral (sensorimotor) STN seems the main DBS effector. The highest spontaneous neuron activity seems related to the anterior (rostral) ventromedial (limbic) STN. Conclusion 1.5 Tesla images provide sufficiently detailed sub-thalamic anatomy for image-guided stereotactic surgery and may aid in understanding DBS mechanisms.
Type de document :
Article dans une revue
International Journal of Computer Assisted Radiology and Surgery, Springer Verlag, 2007, 2 (2), pp.75-85. 〈10.1007/s11548-007-0124-2〉
Liste complète des métadonnées

Littérature citée [47 références]  Voir  Masquer  Télécharger

https://hal.archives-ouvertes.fr/hal-01543092
Contributeur : Jérôme Coste <>
Soumis le : lundi 26 juin 2017 - 15:11:13
Dernière modification le : mardi 27 juin 2017 - 13:07:50

Fichier

Lemaire_IJCARS_2007.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Jean-Jacques Lemaire, Jerome Coste, Lemlih Ouchchane, Simone Hemm, Philippe Derost, et al.. MRI anatomical mapping and direct stereotactic targeting in the subthalamic region: functional and anatomical correspondence in Parkinson?s disease. International Journal of Computer Assisted Radiology and Surgery, Springer Verlag, 2007, 2 (2), pp.75-85. 〈10.1007/s11548-007-0124-2〉. 〈hal-01543092〉

Partager

Métriques

Consultations de
la notice

61

Téléchargements du document

43