Ehrlichia's molecular tricks to manipulate their host cells

Amal Moumene (1, 2) , Damien Meyer (1)

1 UMR CMAEE - Contrôle des maladies animales exotiques et émergentes
2 UAG - Université des Antilles et de la Guyane

Ehrlichia is a large genus of obligate intracellular Gram-negative bacteria transmitted by ticks that cause several emerging infectious diseases in humans and are pathogenic on rodents, ruminants, and dogs. Ehrlichia spp. invade and replicate either in endothelial cells, white blood cells, or within midgut cells and salivary glands of their vector ticks. In this review, we discuss the insights that functional studies are providing on how this group of bacteria exploits their host by subverting host innate immunity and hijacking cellular processes.

Mots clés: ehrlichia; bacterial-host interaction; effectors; T4SS; gram negative bacteria; endothelial cell; infectious disease

Mots clés: bactérie gram négatif; tique; cowdria; cellule endotheliale; hôte; maladie infectieuse; immunité innée

Domaines: Biodiversité et Ecologie

Amal Moumene, Damien Meyer. Ehrlichia's molecular tricks to manipulate their host cells. Microbes and Infection, 2016, 18 (3), pp.172-179. ⟨10.1016/j.micinf.2015.11.001⟩. ⟨hal-01512099⟩