Preparation and Characterization of Metal Oxide as Nano Particles -Varatika Bhasma
Résumé
Varatika bhasma is a herbomineral formulation coming under the holistic concept of Ayurveda. Varatika is the outer covering shell of marine organism Cyprea moneta Linn or commonly known as Money cowry. Chemical composition of Varatka is Calcium carbonate. The present study involves the processing of varatika in to metal oxides by a special process known as Bhasmikaran in Ayurveda, the ancient system of medicine. Varatika is subjected to calcination there by the Calcium carbonate present in varatika is converted fine particles of calcium oxide, producing potent, biosafe and efficacious nanoparticles with less side effects are produced. The evaluation of the final product are done for physicochemical parameters and by sophisticated analytical tools like Xray, SEM, AFM, Zeta potential EDAX, particle size analysis and by Thermogravimetric curves. The produced bhasma was found as very fine nano particle which may produce very potent and biosafe antiulcer activity. Introduction: Ayurveda is an ancient system of medicine where natural materials are used as remedies for a large no of diseases and the system is based upon the balance of spiritual mental and and physical functions of human body. A large number of formulations are available in ayurvedic system.Out of this 35-40% contains minimum one metals as major ingredient. A branch of Ayurveda known as Rasoushadi includes a class of ayurvedic medicines containing metals. Bhasma are coming under rasoushadies as they are herbo-metallic ashes prepared by repeated calcination of metals with various herbal ingredients to form organometallic complexes [3] These process known as Bhasmikarn converts metals in to metal oxides of nanosize having unique electrical, optical catalytical and medicinal properties. These formulations are very very important because of their uniqueness like alpamathra (a low dose), non toxicity, good palatability and potent and fast acting and with the ability of targeted drug delivary.In this present study Varatika bhasma is prepared from the outer covering of the marine organism Cyprea moneta Linn or commonly known as Money cowry.This is mainly used for its antiulcer property as it contains calcium carbonate. Varatika is subjected to bhasmikaran process whereby the organic components are eliminated and metals are converted to its high oxygenated state. The repeated heating reduces the particle size to nanosize whereby nano medicine with increasedmetabolism at cellular level because of its high zetapotential and rapidly acting, nontoxic less side effects producing herbo mineral formulation Varatika Bhasma is obtained. This study also attempts to characterize the varatika bhasma prepared by physico-chemical properties through conventional methods like Nischandratvam (lusterless), Apunarbhava (metal irreversibility test), Varitaratvam (floating test) and by physicochemical parameters and using modern analytical methods likescanning electron microscope (SEM)and X-ray fluorescence (XRF) spectrophotometer [2-5].
Domaines
Matériaux
Origine : Accord explicite pour ce dépôt
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