Synthesis of Pure Hydroxyapatite (Ca10 (PO4)6 (OH)2 ) by the Sol –Gel Method and the Doxycycline Loaded in Presence of Gelatin for the Application of Drug Delivery

B Shalini (1) , A Ruban Kumar (1) , A Mary Saral (1)

1 VIT University

Hydroxyapatite (HAp) is the most widely accepted biomaterial for the repair and reconstruction of bone tissue defects. The current study is based on HAp was synthesized using sol-gel method. The drug was loaded in presence of gelatin with pure HAp. Precursors like calcium nitrate tetrahydrate and diammonium hydrogen orthophosphate were used and ammonia solution was added to maintain the pH value at 10.5 throughout the reaction. The synthesized HAp and drug loaded HAp with gelatin were characterized using PXRD, FTIR, SEM, Drug loading, drug release studies. Results show that the average crystallite size for prepared HAp and drug loaded HAp with polymer are ~ 30 to 300 nm respectively was calculated using PXRD and morphology of pure HAp and drug loaded HAp with polymer was found using SEM. Drug loading and release percentage was calculated. Keeping the above points in the present study was aimed to produce the biocompatibility and bioactivity of HAp.

Mots clés: hydroxyapatite; sol gel process; PXRD; FT-IR; SEM; drug loading and releasing

Domaines: Chimie thérapeutique; Matériaux; Pharmacie galénique

B Shalini, A Ruban Kumar, A Mary Saral. Synthesis of Pure Hydroxyapatite (Ca10 (PO4)6 (OH)2 ) by the Sol –Gel Method and the Doxycycline Loaded in Presence of Gelatin for the Application of Drug Delivery. Mechanics, Materials Science & Engineering Journal, 2017, 9 (1), ⟨10.2412/mmse.89.93.112⟩. ⟨hal-01496395⟩