Extraction of trans-resveratrol from red wine and optimization by response surface methodology

Mihasina Rabesiaka , Lovasoa Rakotondramasy-Rabesiaka (1) , Isabelle Mabille (2) , Catherine Porte (1) , Jean-Louis Havet (1)

1 LGP2ES - Laboratoire Génie des Procédés pour l'Environnement, l'Energie et la Santé
2 LGPPTS - Laboratoire Génie des Procédés Plasmas et Traitement de Surface

The optimization of liquid–liquid extraction of resveratrol from wine by organic solvent was investigated using a Doehlert design. Preliminary experiments were conducted to choose the solvent used for the experimental design. Two parameters were analysed: the composition of the binary solvent mixture and the solution/solvent ratio. The best result was obtained by superimposing the isoresponses of selectivity and yield. The optimum operating conditions for extraction were: (i) a solvent mixture of cyclohexane/pentanol with a weight ratio of 40/60 and (ii) a solution/solvent ratio of 30/70. Under these conditions, the yield is above 95% for a selectivity of about 6.6‰.

Domaines: Génie des procédés

Mihasina Rabesiaka, Lovasoa Rakotondramasy-Rabesiaka, Isabelle Mabille, Catherine Porte, Jean-Louis Havet. Extraction of trans-resveratrol from red wine and optimization by response surface methodology. Separation and Purification Technology, 2011, 81 (1), pp.56 - 61. ⟨10.1016/j.seppur.2011.06.042⟩. ⟨hal-01488322⟩