A Comparative Study of Perfusion Measurement in Brain Tumours at 3 Tesla MR : Arterial Spin Labeling versus Dynamic Susceptibility Contrast-Enhanced MRI

Pierre Lehmann , Pauline Monet (1) , Giovanni de Marco (2) , Guillaume Saliou , Muriel Perrin , Souraya Stoquart-Elsankari , Alexis Bruniau , Jean-Noël Vallée

1 Service de radiologie
2 CeRSM - Centre de Recherche sur le Sport et le Mouvement

PURPOSE: To prove the feasibility of arterial spin labeling (ASL) to explore brain tumors by comparing dynamic susceptibility contrast-enhanced MRI to ASL at 3T MR. MATERIALS AND METHODS: Twenty-seven patients were included presenting 9 gliomas, 10 metastases and 8 meningiomas. All were explored by a pseudo-continuous ASL and dynamic susceptibility contrast-enhanced T2* perfusion sequence. Two neuroradiologists analyzed the cerebral blood flow (CBF) maps to assess feasibility, examination quality and quantitative comparison. The Spearman nonparametric correlation test and the Bland-Altman graphic test were used to analyze our quantitative results. RESULTS: 92% of ASL CBF maps were informative. ASL detected all lesions as well as dynamic susceptibility contrast-enhanced MRI. Both sequences provide relative quantitative CBF values closely correlated. CONCLUSION: On a 3T MR unit, ASL is a good alternative to dynamic susceptibility contrast-enhanced MRI when contrast medium is contraindicated or intravenous injection is not possible. Its results on relative CBF parameters are similar to contrast-injected perfusion.

Mots clés: Perfusion; Cerebral blood flow; Cerebral neoplasm; 3T MR; Arterial spin labeling

Domaines: Biomécanique [physics.med-ph]; Physiologie [q-bio.TO]; Imagerie

Pierre Lehmann, Pauline Monet, Giovanni de Marco, Guillaume Saliou, Muriel Perrin, et al.. A Comparative Study of Perfusion Measurement in Brain Tumours at 3 Tesla MR : Arterial Spin Labeling versus Dynamic Susceptibility Contrast-Enhanced MRI. European Neurology, 2010, 64 (1), pp.21-26. ⟨10.1159/000311520⟩. ⟨hal-01469470⟩