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Biomarkers associated with checkpoint inhibitors

Abstract : Checkpoint inhibitors (CPI), namely anti-CTLA4 and anti-PD1/PD-L1 antibodies, demonstrated efficacy across multiple types of cancer. However, only subgroups of patients respond to these therapies. Additionally, CPI can induce severe immune-related adverse events (irAE). Biomarkers that predict efficacy and toxicity may help define the patients who may benefit the most from these costly and potentially toxic therapies. In this study, we review the main biomarkers that have been associated with the efficacy (pharmacodynamics and clinical benefit) and the toxicity (irAE) of CPIs in patients.
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Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Friday, October 7, 2016 - 10:04:05 AM
Last modification on : Monday, November 28, 2022 - 10:38:07 AM


Biomarkers Associated with Che...
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G. Manson, J. Norwood, A. Marabelle, H. Kohrt, R. Houot. Biomarkers associated with checkpoint inhibitors. Annals of Oncology, 2016, 27 (7), pp.1199--1206. ⟨10.1093/annonc/mdw181⟩. ⟨hal-01359396⟩



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