miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy

Marie-Flore Hennino (1, 2) , David Buob (3, 4) , Cynthia van Der Hauwaert (2) , Viviane Gnemmi (5) , Zacharie Jomaa (6) , Nicolas Pottier (2) , Grégoire Savary (2) , Elodie Drumez (7) , Christian Noël (8) , Christelle Cauffiez (2) , François Glowacki (2)

1 Centre hospitalier [Valenciennes, Nord]
2 IMPECS - Impact de l'environnement chimique sur la santé humaine - ULR 4483
3 CHU Tenon [AP-HP]
4 UPMC - Université Pierre et Marie Curie - Paris 6
5 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
6 Dpt néphrologie [CHU Cambrai]
7 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
8 LIRIC - Lille Inflammation Research International Center - U 995

IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, whose prognosis is highly variable. Interstitial fibrosis is a strong independent prognosis factor. Among microRNA involved in renal fibrogenesis, only few have been investigated in IgAN. In the context of IgAN, we aimed to analyze the role of miR-21-5p, miR-214-3p and miR-199a-5p, three established “fibromiRs” involved in renal fibrosis. Fifty-six IgAN biopsy specimens were retrospectively scored according to Oxford classification. Renal expression of miR-21-5p, miR-214-3p and miR-199a-5p were significantly associated with T score (miR-21-5p T0 RQ median = 1.23, T1 RQ = 3.01, T2 RQ = 3.90; miR-214-5p T0 RQ = 1.39, T1 RQ = 2.20, T2 RQ = 2.48; miR-199a-5p T0 RQ = 0.76, T1 RQ = 1.41, T2 RQ = 1.87). miR-21-5p expression was associated with S score (S0 RQ median = 1.31, S1 RQ = 2.65), but not miR-214-3p nor miR-199a-5p. In our cohort, poor renal survival was associated with high blood pressure, proteinuria and elevated creatininemia, as well as T and S scores. Moreover, renal expression of miR-21-5p, miR-214-3p were associated with renal survival. In conclusion, miR-21-5p, miR-214-3p and miR-199a-5p are three “fibromiRs” involved in renal fibrosis in the course of IgAN and miR-21-5p and miR-214-3p are associated with renal survival.

Domaines: Urologie et Néphrologie

Marie-Flore Hennino, David Buob, Cynthia van Der Hauwaert, Viviane Gnemmi, Zacharie Jomaa, et al.. miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy. Scientific Reports, 2016, 6, pp.27209. ⟨10.1038/srep27209⟩. ⟨hal-01339801⟩