High-pressure processing of milk alleviates atopic dermatitis in DNCB-induced Balb/c mice

Jieun Lee , Eun-Ji Choi , Sun Young Park , Ga Young Jeon , Ja-Young Jang , Young Jun Oh , Seul Ki Lim , Min-Sung Kwon , Tae-Woon Kim , Jong-Hee Lee , Hae Woong Park , Hyun Ju Kim , Jong Soo Kang , Jung Tae Jeon , Hak-Jong Choi

AbstractHigh pressure (HP) is recognized as the alternative process technology of heat treatment in food production. Although milk was the first food product to be treated with HP, the allergenicity of HP-treated milk remains to be elucidated. Thus, this study was conducted to investigate the effects of HP treatment on the alleviation of atopic dermatitis (AD) caused by milk in a mouse model. To investigate the effect of HP treatment on the alleviation of AD, Balb/c mice were fed HP-treated milk orally for 7 days following induction of AD with 1-chloro-2,4-dinitro-benzene (DNCB). Mice fed with HP-treated milk exhibited markedly lower serum IgE level than DNCB-treated mice. These results suggest that HP may be applicable as an alternative process for the development of hypoallergenic milk products.

Mots clés: High pressure; Milk; Atopic dermatitis

Domaines: Sciences du Vivant [q-bio]

Jieun Lee, Eun-Ji Choi, Sun Young Park, Ga Young Jeon, Ja-Young Jang, et al.. High-pressure processing of milk alleviates atopic dermatitis in DNCB-induced Balb/c mice. Dairy Science & Technology, 2016, 96 (1), pp.67-78. ⟨10.1007/s13594-015-0239-0⟩. ⟨hal-01336307⟩