Optimal estimation of diffusion in DW-MRI by high-order MRF-based joint deformable registration and diffusion modeling

Abstract : Over the last years, the apparent diffusion coefficient (ADC), computed from diffusion-weighted magnetic resonance (DW-MR) images, has become an important imaging biomarker for evaluating and managing patients with neoplastic or cerebrovascular disease. Standard methods for the calculation of ADC ignore the presence of noise and motion between successive (in time) DW-MR images acquired by changing the b-value. In order to accurately quantify the diffusion process during image acquisition, we introduce a method based on a high-order Markov Random Field (MRF) formulation that jointly registers the DW-MR images and models the spatiotemporal diffusion. Spatial smoothness on the ADC map, as well as spatiotempo-ral deformation smoothness, is imposed towards producing anatomically meaningful representations. The high-order dependencies in our MRF model are handled through Dual Decomposition. Performance of registration is compared to a state-of-the art registration approach in terms of obtained fitting error of the diffusion model in the core of the tumor. Preliminary results reveal a marginally better performance of our method when compared against the standard ADC map used in clinical practice, which indicates its potential as a means for extracting imaging biomarkers.
Document type :
Conference papers
Liste complète des métadonnées

Cited literature [30 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-01324229
Contributor : Evgenios N. Kornaropoulos <>
Submitted on : Tuesday, May 31, 2016 - 5:17:18 PM
Last modification on : Thursday, February 7, 2019 - 5:29:18 PM
Document(s) archivé(s) le : Thursday, September 1, 2016 - 11:23:47 AM

File

WBIR16_Joint_DWI_Registration_...
Files produced by the author(s)

Identifiers

  • HAL Id : hal-01324229, version 1

Citation

Evgenios N. Kornaropoulos, Evangelia I. Zacharaki, Pierre Zerbib, Chieh Lin, Alain Rahmouni, et al.. Optimal estimation of diffusion in DW-MRI by high-order MRF-based joint deformable registration and diffusion modeling. WBIR 2016 - 7th International Workshop on Biomedical Image Registration , Jul 2016, Las Vegas, Nevada, United States. ⟨hal-01324229⟩

Share

Metrics

Record views

252

Files downloads

302