Identification in GRMD dog muscle of critical miRNAs involved in pathophysiology and effects associated with MuStem cell transplantation.

Florence Robriquet (1) , Candice Babarit (1) , Thibaut Larcher (1) , Laurence Dubreil (1) , Mireille Ledevin (1) , Hélicia Goubin (1) , Karl Rouger (1) , Laétitia Guével (1)

1 PAnTher - Physiopathologie Animale et bioThérapie du muscle et du système nerveux

We point out a differential muscle expression of miR-222 and miR-486 associated with the pathophysiology of the clinically relevant GRMD dog model with a tissue localization focused on regenerated fibres. We also establish a modified expression of miR-133a and miR-222 subsequent to MuStem cell infusion.

Mots clés: miRNA; In situ hybridization; Skeletal muscle; Stem cell therapy; Duchenne muscular dystrophy; GRMD dog

Domaines: Médecine humaine et pathologie

Florence Robriquet, Candice Babarit, Thibaut Larcher, Laurence Dubreil, Mireille Ledevin, et al.. Identification in GRMD dog muscle of critical miRNAs involved in pathophysiology and effects associated with MuStem cell transplantation.. BMC Musculoskeletal Disorders, 2016, 17 (1), pp.209. ⟨10.1186/s12891-016-1060-5⟩. ⟨hal-01321085⟩