Regulatory B lymphocyte functions should be considered in chronic lymphocytic leukemia.

Audrey Mohr (1, 2) , Yves Renaudineau (3, 1) , Cristina Bagacean (1, 2) , Jacques-Olivier Pers (1) , Christophe Jamin (1, 2) , Anne Bordron (2, 1)

1 LBAI - Lymphocytes B, Autoimmunité et Immunothérapies
2 LabEX IGO Immunothérapie Grand Ouest
3 Laboratoire d'Immunologie et Immunothérapie

Chronic lymphocytic leukemia (CLL) is characterized by an abnormal expansion of mature B cells in the bone marrow and their accumulation in blood and secondary lymphoid organs. Tumor CLL cells share expression of various surface molecules with many subsets of B cells and have several common characteristics with regulatory B cells (B regs). However, the identification of B regs and their role in CLL remain elusive. The aim of this review is to summarize recent works regarding the regulatory and phenotypic characteristic of B regs and their associated effects on the immune system. It is also meant to highlight their potential importance with regards to the immunotherapeutic response.

Mots clés: B lymphocytes; CLL; immunotherapy; regulatory B cell

Domaines: Immunologie

Audrey Mohr, Yves Renaudineau, Cristina Bagacean, Jacques-Olivier Pers, Christophe Jamin, et al.. Regulatory B lymphocyte functions should be considered in chronic lymphocytic leukemia.. OncoImmunology, 2016, 5 (5), pp.e1132977. ⟨hal-01515229⟩